Role of RAS in bone remodeling and protective effect of ARB on bone density

本研究表明，Ang II促进软骨细胞的肥大分化，不依赖于高血压，导致骨折愈合延迟。这些数据将为以RAS为核心的软骨退行性疾病提供新的治疗策略。此外，我们的临床研究也证实了ARB对高血压患者骨吸收的抑制作用，如高龄卧床妇女废用综合征。在老年高血压患者中，ARB除了具有降压作用外，可能还具有维持卧床患者骨骼健康的额外有益潜力。

The present study demonstrated that Ang II promoted hypertrophic differentiation of chondrocytes independently of high blood pressure, resulting in the delay of fracture healing. These data would provide a new therapeutic strategy focusing on RAS for cartilage degenerative disease.Also, our clinical study demonstrated the inhibitory effects of ARB on bone resorption in the hypertensive patients with accelerated bone resorption such as high-aged bed-ridden women with disuse syndrome. In the elderly hypertensive patients, ARB might be expected to have additional beneficial potential to maintain the bone health in bed-ridden patients, beyond its blood pressure-lowering effect.