Membrane Function and Bone-Metabolism in the Pathophysiology of the Metabolic Syndrome

代谢综合征病理生理学中的膜功能和骨代谢

• 批准号: 23590901
• 负责人: TSUDA KAZUSHI
• 金额: $ 3.24万
• 依托单位: Kansai University of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590901/
• 关键词: 高血圧; メタボリックシンドローム; 細胞膜fluidity; 電子スピン共鳴; 赤血球; nitric oxide; 酸化ストレス; 慢性腎臓病; adipocytokine; 微小循環; microcirculation

The purpose of the present study was to examine possible relationship between kidney function and membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive subjects using an electron spin resonance and spin-labeling method. Membrane fluidity was significantly decreased in hypertensive subjects. The decreased eGFR value might be associated with reduced membrane fluidity of RBCs, suggesting that CKD might have a close correlation with microcirculatory disorders. The reduced levels of both membrane fluidity of RBCs and eGFR were associated with increased plasma 8-iso-prostaglandin F2alpha (an index of oxidative stress) and decreased plasma nitric oxide-metabolites. On the other hand, bone mineral density was significantly lower in hypertensive elderly women than in normotensive elderly women. We propose that CKD-related changes in membrane function and bone-metabolism might have a crucial role in the pathophysiology of hypertension and the metabolic syndrome.

本研究的目的是利用电子自旋共振和自旋标记方法研究高血压和正常血压受试者肾功能和红细胞膜流动性之间的可能关系。高血压患者的膜流动性明显降低。eGFR值降低可能与红细胞膜流动性降低有关，提示CKD可能与微循环疾病密切相关。红细胞和eGFR的膜流动性水平降低与血浆8-异前列腺素f2α（氧化应激指标）升高和血浆一氧化氮代谢物降低有关。另一方面，高血压老年妇女的骨密度明显低于正常老年妇女。我们认为ckd相关的膜功能和骨代谢的改变可能在高血压和代谢综合征的病理生理中起重要作用。

项目成果

Asymmetric dimethylarginine and DDAH transcript variants in cardio- vascular and cerebrovascular diseases

心脑血管疾病中的不对称二甲基精氨酸和DDAH转录变异

• 发表时间: 2014
• 期刊: Am J Hypertens
• 影响因子: 3.2
• 作者: 青木元邦;湯久浩;守口篤;志水秀朗;中神啓徳;荻原俊男;森下竜一;青木元邦;Tsuda K;Tsuda K;Tsuda K
• 通讯作者: Tsuda K

Letter Regarding Article, Vitamin D deficiency is associated with subclinical carotid atherosclerosis: the Northern Manhattan study.

关于文章的信函：维生素 D 缺乏与亚临床颈动脉粥样硬化有关：曼哈顿北部研究。

• DOI: 10.1161/strokeaha.111.634154
• 发表时间: 2011
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Kazushi Tsuda;et al.
• 通讯作者: et al.

Letter Regarding Article, Receptor activity-modifying protein-1 augments cerebrovascular responses to calcitonin gene-related peptide and inhibits angiotensin II-induced vascular dysfunction.

关于文章的信件，受体活性修饰蛋白-1 增强脑血管对降钙素基因相关肽的反应，并抑制血管紧张素 II 诱导的血管功能障碍。

• DOI: 10.1161/strokeaha.110.604272
• 发表时间: 2011
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Kazushi Tsuda;et al.
• 通讯作者: et al.

Retinol-binding protein 4 predicts membrane microviscosity of red blood cells and microcirculatory dysfunction in hypertension via inflammation and endothelial dysfunction.

视黄醇结合蛋白 4 通过炎症和内皮功能障碍预测红细胞膜微粘度和高血压的微循环功能障碍。

• 发表时间: 2014
• 作者: Kazushi Tsuda;et al.;Kazushi Tsuda
• 通讯作者: Kazushi Tsuda

細胞膜機能からみた高血圧の血管内皮障害とAdipokineによる調節機構-電子スピン共鳴法を用いた検討-．

从细胞膜功能角度探讨高血压血管内皮功能障碍及其脂肪因子的调节机制——电子自旋共振研究。

• 发表时间: 2013
• 作者: Kazushi Tsuda;et al.;Kazushi Tsuda;Kazushi Tsuda;津田和志;Tsuda K;Tsuda K;津田和志
• 通讯作者: 津田和志