Membrane Function and Bone-Metabolism in the Pathophysiology of the Metabolic Syndrome

本研究的目的是利用电子自旋共振和自旋标记方法研究高血压和正常血压受试者肾功能和红细胞膜流动性之间的可能关系。高血压患者的膜流动性明显降低。eGFR值降低可能与红细胞膜流动性降低有关，提示CKD可能与微循环疾病密切相关。红细胞和eGFR的膜流动性水平降低与血浆8-异前列腺素f2α（氧化应激指标）升高和血浆一氧化氮代谢物降低有关。另一方面，高血压老年妇女的骨密度明显低于正常老年妇女。我们认为ckd相关的膜功能和骨代谢的改变可能在高血压和代谢综合征的病理生理中起重要作用。

The purpose of the present study was to examine possible relationship between kidney function and membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive subjects using an electron spin resonance and spin-labeling method. Membrane fluidity was significantly decreased in hypertensive subjects. The decreased eGFR value might be associated with reduced membrane fluidity of RBCs, suggesting that CKD might have a close correlation with microcirculatory disorders. The reduced levels of both membrane fluidity of RBCs and eGFR were associated with increased plasma 8-iso-prostaglandin F2alpha (an index of oxidative stress) and decreased plasma nitric oxide-metabolites. On the other hand, bone mineral density was significantly lower in hypertensive elderly women than in normotensive elderly women. We propose that CKD-related changes in membrane function and bone-metabolism might have a crucial role in the pathophysiology of hypertension and the metabolic syndrome.