Mechanism of EBV-mediated gastric carcinogenesis depending on TLR3 signals
Mechanism of EBV-mediated gastric carcinogenesis depending on TLR3 signals
批准号:
23590909
负责人:
IWAKIRI Dai
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
We have demonstrated that EBV-encoded small RNA (EBER) is released by EBV-infected gastric cancer cells and released EBER triggers the signaling from toll-like receptor 3, a sensor of viral RNA. Further study indicated that EBER-mediated activation of TLR3 signals led to the growth promotion of EBV-infected gastric cancer cells, suggesting that EBER contribute to gastric carcinogenesis through TLR3 activation. We also demonstrated that latent membrane protein 2A (LMP2A) confers anoikis resistance to EBV-infected epithelial cells, leading to epithelial malignancy.
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EBウイルスによる発癌の分子機構
EB病毒致癌的分子机制
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Jin X., Tsuda T., Tsuda H., Hamasaki N., 諸井雅男, 岩切大]
通讯作者:
岩切大
Epstein-Barr virus latent membrane 2A contributes to anoikis resitance through ERK activation
Epstein-Barr病毒潜伏膜2A通过ERK激活促进失巢凋亡抵抗
DOI:
--
发表时间:
2013
期刊:
J. VIrol
影响因子:
--
作者:
[Iwakiri, D., Minanitani, T., Samanta, M]
通讯作者:
M
EBV-encoded small RNA is secreted via exosomes in gastric epithelial cells.
EBV 编码的小 RNA 通过胃上皮细胞的外泌体分泌。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Iwakiri D., Takada K.]
通讯作者:
Takada K.
EBV-encoded small RNA is secreted via exosomes in gastric epithelial cells
EBV编码的小RNA通过胃上皮细胞中的外泌体分泌
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Iwakiri, D., Minamitani, T., Takada, K.]
通讯作者:
K.
DOI:
10.1128/jvi.01089-13
发表时间:
2013-07-01
期刊:
JOURNAL OF VIROLOGY
影响因子:
5.4
作者:
[Iwakiri, Dai, Minamitani, Takeharu, Samanta, Mrinal]
通讯作者:
Samanta, Mrinal
共 12 条
Study of mechanism of Epstein-Barr virus-encoded small RNA-mediated gastric carcinogenesis
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批准号:18590664
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.51万
-
财政年份:2006
-
负责人:IWAKIRI Dai
-
依托单位:
Study of mechanism of gastric carcinogenesis associated with EBV-mediated IGF-1 induction
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批准号:16590566
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2004
-
负责人:IWAKIRI Dai
-
依托单位:
海外基金