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Mechanism of EBV-mediated gastric carcinogenesis depending on TLR3 signals

Mechanism of EBV-mediated gastric carcinogenesis depending on TLR3 signals
EBV介导的胃癌发生机制依赖于TLR3信号
批准号:
23590909
负责人:
IWAKIRI Dai
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
We have demonstrated that EBV-encoded small RNA (EBER) is released by EBV-infected gastric cancer cells and released EBER triggers the signaling from toll-like receptor 3, a sensor of viral RNA. Further study indicated that EBER-mediated activation of TLR3 signals led to the growth promotion of EBV-infected gastric cancer cells, suggesting that EBER contribute to gastric carcinogenesis through TLR3 activation. We also demonstrated that latent membrane protein 2A (LMP2A) confers anoikis resistance to EBV-infected epithelial cells, leading to epithelial malignancy.
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EBウイルスによる発癌の分子機構
EB病毒致癌的分子机制
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Jin X., Tsuda T., Tsuda H., Hamasaki N., 諸井雅男, 岩切大]
通讯作者: 岩切大
Epstein-Barr virus latent membrane 2A contributes to anoikis resitance through ERK activation
Epstein-Barr病毒潜伏膜2A通过ERK激活促进失巢凋亡抵抗
DOI: --
发表时间: 2013
期刊: J. VIrol
影响因子: --
作者: [Iwakiri, D., Minanitani, T., Samanta, M]
通讯作者: M
EBV-encoded small RNA is secreted via exosomes in gastric epithelial cells.
EBV 编码的小 RNA 通过胃上皮细胞的外泌体分泌。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Iwakiri D., Takada K.]
通讯作者: Takada K.
EBV-encoded small RNA is secreted via exosomes in gastric epithelial cells
EBV编码的小RNA通过胃上皮细胞中的外泌体分泌
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Iwakiri, D., Minamitani, T., Takada, K.]
通讯作者: K.
12
    Study of mechanism of Epstein-Barr virus-encoded small RNA-mediated gastric carcinogenesis
    • 批准号:
      18590664
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.51万
    • 财政年份:
      2006
    • 负责人:
      IWAKIRI Dai
    • 依托单位:
    Study of mechanism of gastric carcinogenesis associated with EBV-mediated IGF-1 induction
    • 批准号:
      16590566
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2004
    • 负责人:
      IWAKIRI Dai
    • 依托单位:
    海外基金