Gene analysis of gastrointestinal (esophagus, stomach and colorectum) cancer related with pathogenesis and treatment

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The aim of this study is to establish a method to optimal choice of treatment by analyzing correlation between biological features of tumor including DNA methylation and gene expression and clinical courses of gastrointestinal cancer. We established drug-resistant cancer cell line by exposure with anticancer drugs, and obtained endoscopic biopsy specimens before and after chemotherapy. We performed genome-wide analysis with microarray. We analyzed DNA methylation and gene expression profiles related with drug-resistant of gastrointestinal cancer. And we extracted genes that were considered to be important for drug-resistant mechanisms using quantitative methods.