Development of novel PDT with glucose-conjugated chlorin for gastric cancer and GIST

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Except for surgical resection, no effective treatment strategies have been established for gastrointestinal stromal tumors (GISTs). Photodynamic therapy (PDT) consists of intravenous administration of a photosensitizer, activated by a specific wavelength of light, which produces reactive oxygen species that directly kill tumor cells. We analyzed the efficacy of PDT using a newly developed photosensitizer, glucose-conjugated chlorin (G-chlorin) for the GIST treatment. In vitro, the expression of the glucose transporters GLUT1, GLUT3, and GLUT4, the cellular uptake of G-chlorin, and apoptosis mediated by PDT with G-chlorin were significantly higher in GIST-T1 than in WI-38 cells. In vivo, G-chlorin accumulation was higher in xenograft tumors of GIST-T1 cells than in the adjacent normal tissue, and tumor growth was significantly suppressed following PDT.