Investigation of the role of mucosal inductive site and indigenous bacteria on the NSAID-induced enteropathy

我们研究了Peyer’s patches （PPs）在非甾体抗炎药（NSAID）诱导的小鼠肠病模型中的作用。我们发现PP-null小鼠比野生型小鼠表现出更大的吲哚美辛诱导的肠病。吲哚美辛治疗后，PPs细胞中CD103+ dc和IL-10表达CD4+ T细胞的比例升高。保护作用与共生菌无关。这些结果表明，PPs在非甾体抗炎药诱导的肠病中发挥保护作用，这种保护作用与肠道中CD103+ dc和IL-10产生CD4+ T细胞的增加有关。PPs被认为是消化炎性疾病的靶点。

We investigated the role of Peyer's patches (PPs) in mouse model of non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy. We found PP-null mice showed greater indomethacin-induced enteropathy than the wild type mice. The proportion of CD103+ DCs and IL-10 expressing CD4+ T cells of PPs increased after indomethacin treatment. Protective effect was not associated with commensal bacteria. These results indicate that PPs play a protective role in NSAID-induced enteropathy, and this protection is associated with an increase in CD103+ DCs and IL-10 producing CD4+ T cells in the intestine. PPs are considered to be a target for digestive inflammatory diseases.