The role of HSP27 in the anti-tumor action of gemcitabine for pancreatic cancer

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We here revealed that phosphorylated HSP27 (P-HSP27) played a key role in gemcitabine (GEM)-induced apoptosis in pancreatic cancer derived cell line. Furthermore, the level of P-HSP27 was a factor to determine the sensitivity to GEM from the results of siRNA and inhibitor experiments. In addition, we examine the clinical significance of investigating the expression levels of HSP27 or P-HSP27 in the biopsied specimen of the pancreatic cancer using endoscopic ultrasound -guided fine needle aspiration (EUS-FNA) technique. As a result, the expression level of P-HSP27 was associated with the absence of metastasis and longer survival. These results suggest that the evaluation of the P-HSP27 expression in the biopsy specimen can be a prognostic factor to predict the prognosis. On the other hand, it was failed to proven that the expression level of HSP27 or P-HSP27 was a factor to predict the response to GEM chemotherapy.