Clinical Significance of BAFF and APRIL in AIP

虽然在自身免疫性胰腺炎（AIP）和一些恶性疾病患者中有高水平的血清B细胞活化因子（BAFF）的报道，但其在发病机制中的作用尚不清楚。在本研究中，我们旨在了解BAFF在AIP和胰腺癌（PC）发病中的作用。首先，我们使用PC患者的血清和胰腺组织以及PC细胞系，发现BAFF在转移性晚期PC患者中升高，并通过调节emt相关基因诱导PC细胞的改变。其次，利用AIP患者的血清和胰腺组织，以及具有AIP各种特征的小鼠，我们发现在小鼠的腺泡细胞中特异性地过度表达淋巴素(LT) β导致AIP的特征。

Although high serum levels of B cell-activating factor (BAFF) are reported in patients with autoimmune pancreatitis (AIP) and some malignant diseases, its role in the pathogenesis remains unclear. In this study, we aimed to understand the role of BAFF in the pathogenesis of AIP and pancreatic cancer (PC). First, using serum and pancreatic tissues from patients with PC, and PC cell line, we showed that BAFF was elevated in patients with metastatic advanced PC and induced alterations in PC cells via regulation of EMT-related genes. Second, using serum and pancreatic tissues from patients with AIP, and mice with various features of AIP, we identified that overexpression of lymphotoxin (LT) beta specifically in acinar cells of mice caused features of AIP.