Insulin Resistance as Promoters for Developemnts of Aortic Valve Sclerosis and Coronary Artery Disease

胰岛素抵抗是主动脉瓣硬化和冠状动脉疾病发展的促进因素

• 批准号: 23591044
• 负责人: HIDEYA Yamamoto
• 金额: $ 2.25万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591044/
• 关键词: インスリン抵抗性; 弁膜石灰化; 冠動脈; アディポネクチン; CT; シンチグラフィー; 心エコー図; ストレイン; 大動脈弁石灰化; 心臓CT; 耐糖能障害; メタボリック症候群; 石灰化弁; 冠動脈ＣＴ; プラーク

1. We studied patients with aortic valvular calcification (AVC) assessed by echocardiography had higher rates of induced myocardial ischemia, especially in diabetes mellitus (DM) patients. 2. When AVC scores were measured by cardiac CT, higher AVC score was an independent predictor of cardiac mortality in aortic stenosis (AS) patients. 3. Echocardiographic heart calcification score, the sum of the amounts of AVC, mitral annular, and aortic root calcification, has an independent and incremental prognostic value in a high-risk population. 4. Assessed by two-dimensional speckle-tracking echocardiography, insulin resistance is a powerful independent predictor of subclinical left ventricular dysfunction in patients with AVC and thus may be a novel therapeutic target to prevent subsequent heart failure.

1. 我们研究了超声心动图评估的主动脉瓣钙化（AVC）患者诱发心肌缺血的发生率较高，尤其是糖尿病（DM）患者。2. 当通过心脏CT测量AVC评分时，较高的AVC评分是主动脉瓣狭窄（AS）患者心脏死亡率的独立预测因子。3. 超声心动图心脏钙化评分，即AVC、二尖瓣环和主动脉根部钙化的总和，在高危人群中具有独立的、递增的预后价值。4. 通过二维斑点跟踪超声心动图评估，胰岛素抵抗是AVC患者亚临床左心室功能障碍的一个强有力的独立预测因素，因此可能是预防继发性心力衰竭的一个新的治疗靶点。

项目成果

Association of Left Ventricular Mass and Coronary Atherosclerosis in Cardiac Computed Tomography Angiography

心脏计算机断层扫描血管造影中左心室质量与冠状动脉粥样硬化的关联

• 发表时间: 2012
• 作者: Kunita K;Yamamoto H;Kihara Y;他
• 通讯作者: 他

Rationale and design of the PREDICT (Plaque Registration and Evaluation Detected In Computed Tomography) registry. J Cardiovasc Comp Tomography

PREDICT（计算机断层扫描中检测到的斑块配准和评估）注册表的基本原理和设计。

• DOI: 10.1016/j.jcct.2013.12.004
• 发表时间: 2014
• 期刊: . J Cardiovasc Comput Tomogr
• 作者: Yamamoto Y;Awai K;Kuribayashi S;Kihara Y; on behalf of the PREDICT Investigators.
• 通讯作者: Kihara Y; on behalf of the PREDICT Investigators.

Plenary session; Cardiovascular disease in diabetes mellitus : where are we now? Coronary artery calcium score as a predictor of adverse outcomes in patients with diabetes mellitus

全会;

• 发表时间: 2014
• 作者: Yamamoto H;Kihara Y;他
• 通讯作者: 他

Association Between Aortic Valve Calcification and Myocardial Ischemia, Especially in Asymptomatic Patients

• DOI: 10.2967/jnumed.111.099275
• 发表时间: 2012-08
• 期刊: The Journal of Nuclear Medicine
• 作者: Ryo Yamazato;Hideya Yamamoto;F. Tadehara;H. Teragawa;S. Kurisu;Y. Dohi;Ken Ishibashi;E. Kunita;Hiroto Utsunomiya;Toshiharu Oka;Y. Kihara

Association between heart calcification assessed by echocardiography and future cardiovascular disease mortality and morbidity.

• DOI: 10.1016/j.ijchv.2013.11.007
• 发表时间: 2013-03
• 期刊: International journal of cardiology. Heart & vessels
• 作者: Utsunomiya H;Yamamoto H;Urabe Y;Tsushima H;Kunita E;Kitagawa T;Hidaka T;Kihara Y
• 通讯作者: Kihara Y