The development of a novel modality treating heart failure patients via the improvement of vascular endothelial function by use of whole body periodic acceleration with a motion platform

通过运动平台全身周期性加速改善血管内皮功能，开发治疗心力衰竭患者的新方法

• 批准号: 23591074
• 负责人: MIYAMOTO Shoichi
• 金额: $ 3.33万
• 依托单位: The Tazuke Kofukai
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591074/
• 关键词: 血管内皮機能; 加速ベッド; メタボリック症候群; 慢性心不全

Objectives: We hypothesized that treatment with whole body periodic acceleration (WBPA) reverses left ventricular (LV) remodeling as a result of increased peripheral vasodilatory reserve in patients with old myocardial infarction (OMI). Methods: Thirteen OMI patients years who received full medication were randomly assigned to undergo 20 sessions of mild WBPA (Control group) or regular WBPA with the motion platform for 4 weeks (WBPA group). Mild WBPA was applied at 2 to 3 Hz and approximately +-0.3 m/sec2 for 45 min and regular WBPA was applied at approximately +-2.2 m/sec2. We repeated the blood sampling and treadmill exercise test. Results: Plasma BNP levels significantly decreased in the regular WBPA group. In the regular WBPA group, the exercise time until dyspnea onset significantly increased, and the double product at 0.1 mV ST depression. Conclusions: Treatment with regular WBPA for OMI patients ameliorates exercise capacity through central and peripheral effects.

目的：我们假设全身周期加速（WBPA）治疗可逆转老年性心肌梗死（OMI）患者外周血管舒张储备增加导致的左室（LV）重构。方法：13例接受完整药物治疗的OMI患者，随机分为轻度双酚a组（对照组）和常规双酚a组（运动平台组），两组共20次，为期4周。轻度双酚a以2至3 Hz的频率施加，大约+-0.3 m/sec2，持续45分钟，常规双酚a以大约+-2.2 m/sec2施加。我们重复了血液采样和跑步机运动测试。结果：正常双酚a组血浆BNP水平明显降低。常规WBPA组运动至呼吸困难发作的时间明显增加，双积在0.1 mV ST处下降。结论：常规WBPA治疗可通过中枢和外周作用改善OMI患者的运动能力。

项目成果

加速ベッドは危険因子や心血管疾患を有する患者において運動の代用ツールとなり得る可能性がある

对于有危险因素或心血管疾病的患者来说，加速卧床可以作为运动的替代品

• 作者: 澁谷修司、奥村謙;他;宮本昌一
• 通讯作者: 宮本昌一

冠側副血行循環改善を目指した治療法の開発

开发旨在改善冠状动脉侧支循环的治疗方法

• 发表时间: 2013
• 作者: Tahara A;Tahara N;Honda A;Imaizumi T.;華藤芳輝;宮本昌一
• 通讯作者: 宮本昌一