Elucidation of roles of proteinase-activated receptor in pulmonary hypertension and development of new therapeutic strategies

本研究为内皮屏障功能障碍提供了一种新的机制。 通过使用肺动脉高压动物模型，发现凝血酶受体拮抗剂可以有效地防止肺动脉高压的发展并延长生存期。肺动脉高压时肺动脉收缩反应性增强。因此，凝血酶受体拮抗剂有望成为治疗肺动脉高压的新策略。已提交了肺动脉高压新疗法发明的日本和国际专利提案。

The present study yielded a new mechanism for endothelial barrier dysfunction. By using an animal model of pulmonary hypertension, a thrombin receptor antagonist was found to effectively prevent the development of pulmonary hypertension and prolonged the survival. The contractile responsiveness of pulmonary artery was found to be enhanced in pulmonary hypretension. As a result, thrombin receptor antagonist is suggested to be potentially useful as a new strategy for treatment of pulmonary hypertension. Proposals of Japanese and international patent for the invention of new treatment for pulmonary hypertension has been submitted.