A novel protective strategy for Pseudomonas aeruginosa infection-Development of vaccine using pilus peptide

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Murine naive T cells were incubated with mature dendritic cells stimulated by pili of Pseudomonas aeruginosa or by its peptide. The concentration of cytokines in the culture supernatant stimulated with pili or peptide increased compared to that in control and naive T cells proliferated to mature ones. This result indicates that adaptive immunity by pili but less peptide occurred through dendritic cells. In the future, the efficacy of vaccine by inoculation of pili- or peptide-stimulated mature dendritic cells into mouse should be investigated.