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Regulation of Renal Stem Cell Number by Endothelial Cell-derived Factors

Regulation of Renal Stem Cell Number by Endothelial Cell-derived Factors
内皮细胞衍生因子对肾干细胞数量的调节
批准号：
23591181
负责人：
MAESHIMA AKITO
金额：
$3.16万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591181/
关键词：
腎幹細胞尿細管再生血管内皮由来因子血管内皮細胞加齢

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中文摘要
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英文摘要
We examined the role of endothelial cell-derived factors in growth and differentiation of renal stem cell. Using BrdU labeling method, renal stem cells could be detected as BrdU-positive cells. The number of renal stem cells as well as the interstitial peritubular capillary area decreased with aging. When isolated renal stem cells were co-cultured with HUVEC, the number of renal stem cells significantly increased. HGF induced tube formation in human RPTEC. When RPTEC were co-cultured with HUVEC, tube formation was significantly enhanced. Multiple receptor tyrosine kinases were phosphorylated in RPTEC during tube formation. Collectively, these data suggest the presence of stem cell activators in the endothelial cell-derived factors.
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会议论文
Age-related decline in LRTCｓ
LRTC 与年龄相关的下降
DOI： --
发表时间： 2012
期刊： Am J Physiol Renal Physiol
影响因子： --
作者： [Miya M, Maeshima A, Mishima K, Sakurai N, Ikeuchi H, Kuroiwa T, Hiromura K, Nojima Y., Masaaki Miya]
通讯作者： Masaaki Miya
Quantitative evaluation of epithelial-mesenchymal transition during renal fibrosis
肾纤维化过程中上皮间质转化的定量评估
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Nakasatomi M, Maeshima A, Mishima K, Sakurai N, Ikeuchi H, Sakairi T, Kaneko Y, Hiromura K, Nojima Y]
通讯作者： Nojima Y
腎臓の線維化と再生を担う細胞群を探る「腎尿細管の修復・再生メカニズム」
“肾小管的修复和再生机制”探索负责肾纤维化和再生的细胞群
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Kayakabe K, Kuroiwa T, Sakurai N, Ikeuchi H, Anastasie KT, Sakairi T, Maeshima A, Hiromura K, Nojima Y, 前嶋明人]
通讯作者： 前嶋明人
Involvement of N-type Ca2+ channels in the fibrotic process of the kidney in rats
DOI： 10.1152/ajprenal.00561.2012
发表时间： 2013-03-01
期刊： AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
影响因子： 4.2
作者： [Mishima, Keiichiro, Maeshima, Akito, Nojima, Yoshihisa]
通讯作者： Nojima, Yoshihisa
共 39 条
    Attempt to Regenerate Aging Kidneys Using a Renal Tubule Regeneration System Utilizing Renal Stem Cells
    • 批准号：
      20K08596
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.75万
    • 财政年份：
      2020
    • 负责人：
      MAESHIMA AKITO
    • 依托单位：
      Saitama Medical University
    Mechanism of self-replication and aging in renal stem cells
    • 批准号：
      26461212
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.16万
    • 财政年份：
      2014
    • 负责人：
      MAESHIMA AKITO
    • 依托单位：
      Gunma University