Analysis of DNA repair, cell cycle progression and cell death in dedifferentiation and regeration of renal tubular cells

肾小管细胞去分化和再生过程中 DNA 修复、细胞周期进程和细胞死亡的分析

• 批准号: 23591194
• 负责人: HIRANO SEIKI
• 金额: $ 3.24万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591194/
• 关键词: 腎尿細管障害; 急性腎障害; 細胞周期; DNA修復; 尿細管再生

The number of hemodialysis patient is increasing, which is a critical problem in Japan. To analyze repair and regeneration of renal tubular cells after renal failure will contribute the way of preventive therapy of renal disease. I found that renal tubular cells express the markers of de-differentiation after cell damage and they form tubule when the marker is expressed. I am trying to do further analyses.

血液透析患者的数量正在增加，这在日本是一个严重的问题。分析肾小管细胞在肾功能衰竭后的修复和再生情况，为肾脏疾病的预防治疗提供依据。我发现肾小管细胞在细胞损伤后表达去分化标记物，当该标记物表达时形成小管。我正试着做进一步的分析。

项目成果

Six2-GDNF Pathway Is Activated during Experimental Acute Kidney Injury and Plays a Crucial Role in Renal Tubular Regeneration．

Six2-GDNF 通路在实验性急性肾损伤期间被激活，并在肾小管再生中发挥关键作用。

• 发表时间: 2011
• 作者: Hirano S;Okada N;Urushido M;Bun M;Hisa M;Ogata K;Shimamura Y;Inoue K;Ishihara M;Kagawa T;Takao T;Terada Y
• 通讯作者: Terada Y