A search of factors determining bone quality in patients with chronic kidney disease

慢性肾病患者骨质量影响因素的研究

• 批准号: 23591215
• 负责人: KAZAMA Junichiro
• 金额: $ 1.75万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591215/
• 关键词: 尿毒物質; 骨粗鬆症; 慢性腎臓病; 分光分析; 臨床研究; 弾性力学特性; 尿毒症; 弾性骨強度; 分光生化学; 大規模臨床観察研究; 血液透析; 骨質

We proved the common view that a bone fragility increases in patients with chronic kidney disease by a modern clinical study method. In vivo experimental studies revealed that the contribution of abnormal systemic mineral metabolism to the bone fragility was quite limited while uremic toxins directly and reversibly modified bone material properties that lead a deterioration of bone elastic mechanical properties in uremic condition.From these findings, we proposed a new disease concept of "uremic osteoporosis", which is clearly distinct from CKD-MBD. The concept of direct modification of bone material properties by uremic toxins would not only help improving the clinical practice pattern on bone in patients with chronic kidney disease, but also provide a possible new key to elucidate the pathophysiology of senile osteoporosis.

我们用现代临床研究方法证实了慢性肾脏病患者骨脆性增加的普遍观点。体内实验研究表明，全身性矿物质代谢异常对骨脆性的贡献是有限的，而尿毒症毒素直接可逆地改变骨材料的性质，导致尿毒症条件下骨弹性力学性能的恶化，据此我们提出了一个新的疾病概念“尿毒症性骨质疏松症”，它与CKD-MBD明显不同。尿毒症毒素直接改变骨材料性质的概念不仅有助于改善慢性肾脏病患者的骨临床实践模式，而且可能为阐明老年性骨质疏松症的病理生理机制提供新的钥匙。

项目成果

Accumulated Uremic toxins including Indoxyl Sulfate Disturbs Bone Elastic Properties in Rats with Chronic Kidney Injury

累积的尿毒症毒素（包括硫酸吲哚酚）会扰乱慢性肾损伤大鼠的骨弹性

• 发表时间: 2012
• 作者: Iwasaki Y;Kazama JJ;Yamato H;Fukagawa M
• 通讯作者: Fukagawa M

尿毒症性骨粗鬆症

尿毒症骨质疏松症

• 发表时间: 2013
• 作者: 穆勝宇;下澤達雄;小倉彩世子;王紅;上竹勇三郎;森典子;矢冨裕;藤田敏郎;風間順一郎
• 通讯作者: 風間順一郎

Uremic toxins exacerbate bone mechanical property in chronic kidney disease

尿毒症毒素会加剧慢性肾病患者的骨机械性能

• 发表时间: 2011
• 作者: Iwasaki Y;Kazama JJ;Yamato H;Fukagawa M
• 通讯作者: Fukagawa M

Regional variation in hip fracture incidence among Japanese hemodialysis patients

日本血液透析患者髋部骨折发生率的地区差异

• 发表时间: 2014
• 期刊: Ther Apher Dial
• 影响因子: 1.9
• 作者: Wakasugi M;Kazama JJ;Wada A;Taniguchi M;Tsubakihara Y;Iseki K;Narita I
• 通讯作者: Narita I

慢性腎臓病と骨折

慢性肾病和骨折

• 发表时间: 2012
• 作者: Miyamoto K;et al;風間順一郎
• 通讯作者: 風間順一郎