Molecular mechanisms of tumorigeneis in multiple endocrine neoplasia type 1 (MEN)

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Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited syndrome characterized by the occurrence of tumors in multiple endocrine tissues including parathyroid, enteropancreatic neuroendocrine and anterior pituitary. Although the tissue selectivity of tumors in specific endocrine organs is the essence of MEN1, the mechanisms underlying the tissue-specific tumorigenesis remain unknown. It is known that JunD and MLL, both transcription factors, are main binding partners of menin encoded by MEN1 gene. Through the analysis of mouse models and cDNA microarray, we investigated that JunD and MLL are the key molecules in tumorigenesis of endocrine tissues in MEN1.