Functional analysis of transcription factors regulating brain-spesific expression of aromatase gene

类固醇激素在每个发育阶段都有可逆或不可逆的作用。关于生物体的生物环境适应，类固醇的作用是最有趣的现象之一。类固醇激素在中枢神经系统的功能表达中起着重要作用。在啮齿类动物中，大脑的实质性性别差异是由围产期雌激素的作用决定的。同时，由于芳香化酶基因的表达在围产期短暂增加，可以想象芳香化酶基因的转录调控程序与大脑的性别分化密切相关。在本研究中，为了阐明脑的性别分化，我分析了参与控制芳香酶基因脑特异性表达的转录因子。

Steroid hormones act reversibly or irreversibly in every developmental stage. With regard to the biological environmental adaptation of an organism, the action of the steroid is one of the most interesting phenomena. The steroid hormones take important role that is to function expression of central nervous system. In rodents, the substantial sex differences of the brain are performed by estrogen action in a perinatal period. Meanwhile, since the expression of aromatase gene increases transiently in a perinatal period, it is conceivable that the program of the transcriptional regulation of aromatase gene is deeply concerned with the sexual differentiation of the brain. In this study, to elucidate of the sex differentiation of the brain, I analyzed the transcription factors that take part in the control of the brain-specific expression of the aromatase gene.