Human herpesvirus-6 encephalitis after allogeneic stem cell transplantation: analysis of pathologic condition to predict the development.
同种异体干细胞移植后人类疱疹病毒6型脑炎:分析病理状况以预测发展。
基本信息
- 批准号:23591422
- 负责人:
- 金额:$ 2.91万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 2013
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To elucidate the immunological pathogenesis of human herpesvirus (HHV)-6 encephalitis, we performed detailed cytokine study against 172 HCT recipients, including 20 patients with HHV-6 encephalitis. Seventeen kinds of cytokines in plasma samples collected weekly until 28 days after HCT, and cerebrospinal fluid (CSF) at the time of developing HHV-6 encephalitis were measured. The plasma IL-8, -10, -13, MCP-1, and MIP-1b were significantly higher in patients who developed HHV-6 encephalitis than those without HHV-6 encephalitis. High-level IL-6 predicted poor prognosis for patients with HHV-6 encephalitis. Among patients with HHV-6 encephalitis, IL-5, -6, and -8 in CSF were higher in patients who progress to severe status (died of encephalitis or sequelae) than in other patients. We suggest that several cytokines mediate the pathogenesis of HHV-6 encephalitis. Increased levels of cytokines in plasma and CSF predict development and poor prognosis of HHV-6 encephalitis.
为了阐明人类疱疹病毒6型脑炎的免疫学发病机制,我们对172例HCT受者进行了详细的细胞因子研究,其中包括20例HHV-6脑炎患者。检测HHV-6脑炎发生时的脑脊液和血浆中17种细胞因子的含量。HHV-6脑炎患者血浆IL-8、-10、-13、MCP-1、MIP-1b水平明显高于非HHV-6脑炎患者。高水平IL-6预示HHV-6脑炎患者预后不良。在HHV-6脑炎患者中,病情加重(死于脑炎或后遗症)的患者脑脊液中IL-5、-6和-8的水平高于其他患者。我们认为几种细胞因子参与了HHV-6脑炎的发病过程。血浆和脑脊液中细胞因子水平的升高预示着HHV-6脑炎的发展和预后不良。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Human herpesviruses HHV-6A, HHV-6B & HHV-7. Chapter 13. Zerr DM & Ogata M. HHV-6A and HHV-6B in recipients of hematopoietic cell transplantation
人类疱疹病毒 HHV-6A、HHV-6B
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:Flammand L;Lautenschlager I;Krueger G;Ablashi E (編)
- 通讯作者:Ablashi E (編)
同種造血細胞移植後HHV-6脳炎の発症にはHHV-6再活性化のレベルとIL-6高値が関連する
HHV-6 再激活水平和高 IL-6 水平与异基因造血细胞移植后 HHV-6 脑炎的发生有关。
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Nakayama T;Nishiwaki S;Saito S;Ozaki T;Takahashi Y;Maruyama S;Nishida T;Murata M;Kojima S;Naoe T.;高野久二子
- 通讯作者:高野久二子
Plasma human herpesvirus 6 (HHV-6) DNA loads and interleukin-6 concentration as factors in the development of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation
血浆人疱疹病毒 6 (HHV-6) DNA 载量和白细胞介素 6 浓度是同种异体造血干细胞移植后发生 HHV-6 脑炎的因素
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Takano K;Satou T;Ogata M;Ikewaki J;Kohno K;Miyazaki Y;Ohtsuka E;Saburi Y,Kadota J
- 通讯作者:Saburi Y,Kadota J
Human Herpesvirus 6 (HHV-6) Reactivation and HHV-6 Encephalitis After Allogeneic Hematopoietic Cell Transplantation: A Multicenter, Prospective Study
- DOI:10.1093/cid/cit358
- 发表时间:2013-09-01
- 期刊:
- 影响因子:11.8
- 作者:Ogata, Masao;Satou, Takako;Fukuda, Takahiro
- 通讯作者:Fukuda, Takahiro
Foscarnet against human herpesvirus (HHV)-6 reactivation after allo-SCT: breakthrough HHV-6 encephalitis following antiviral prophylaxis
- DOI:10.1038/bmt.2012.121
- 发表时间:2013-02-01
- 期刊:
- 影响因子:4.8
- 作者:Ogata, M.;Satou, T.;Kadota, J.
- 通讯作者:Kadota, J.
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OGATA Masao其他文献
Linkage between single nucleotide polymorphisms of A20-exon3 and various inflammatory diseases: a study in Oita prefecture.
A20-外显子 3 的单核苷酸多态性与各种炎症性疾病之间的联系:大分县的一项研究。
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
FIFE Nichole;IKEBE Emi;ISHII Koji;OGATA Masao;IMAI Hiromitsu;TAKAHASHI Naohiko;KUBOTA Toshiaki;NISHIZONO Akira;IHA Hidekatsu - 通讯作者:
IHA Hidekatsu
OGATA Masao的其他文献
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{{ truncateString('OGATA Masao', 18)}}的其他基金
Dirac electrons in solids
固体中的狄拉克电子
- 批准号:
24244053 - 财政年份:2012
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Search for novel low-energy states in strongly correlated electron systems
在强相关电子系统中寻找新的低能态
- 批准号:
15540333 - 财政年份:2003
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Theoretical study of anomalous liquid states in low-dimensional fermion systems
低维费米子系统反常液态的理论研究
- 批准号:
10203206 - 财政年份:1998
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas (B)
Theory on vortex states in anisotropic superconductors with strong correlation
强相关各向异性超导体涡旋态理论
- 批准号:
10640334 - 财政年份:1998
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)