Human herpesvirus-6 encephalitis after allogeneic stem cell transplantation: analysis of pathologic condition to predict the development.
Human herpesvirus-6 encephalitis after allogeneic stem cell transplantation: analysis of pathologic condition to predict the development.
批准号:
23591422
负责人:
OGATA Masao
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
为阐明人类疱疹病毒6型脑炎的免疫学发病机制,我们对172例HCT受者进行了详细的细胞因子研究,其中包括20例HHV 6型脑炎患者。每周收集血浆样本,直至HCT后28天,并在HHV-6脑炎时测定脑脊液(CSF)中的17种细胞因子。HHV-6脑炎患者血浆IL-8、IL-10、IL-13、MCP-1和MIP-1b水平明显高于非HHV-6脑炎患者。HHV-6脑炎患者血清IL-6水平升高预示预后不良。在HHV-6脑炎患者中,病情进展至严重状态(死于脑炎或后遗症)的患者CSF中IL-5、IL-6和IL-8水平高于其他患者。我们认为,几种细胞因子介导的HHV-6脑炎的发病机制。血浆和CSF中细胞因子水平升高可预测HHV-6脑炎的发生和预后不良。
英文摘要
To elucidate the immunological pathogenesis of human herpesvirus (HHV)-6 encephalitis, we performed detailed cytokine study against 172 HCT recipients, including 20 patients with HHV-6 encephalitis. Seventeen kinds of cytokines in plasma samples collected weekly until 28 days after HCT, and cerebrospinal fluid (CSF) at the time of developing HHV-6 encephalitis were measured. The plasma IL-8, -10, -13, MCP-1, and MIP-1b were significantly higher in patients who developed HHV-6 encephalitis than those without HHV-6 encephalitis. High-level IL-6 predicted poor prognosis for patients with HHV-6 encephalitis. Among patients with HHV-6 encephalitis, IL-5, -6, and -8 in CSF were higher in patients who progress to severe status (died of encephalitis or sequelae) than in other patients. We suggest that several cytokines mediate the pathogenesis of HHV-6 encephalitis. Increased levels of cytokines in plasma and CSF predict development and poor prognosis of HHV-6 encephalitis.
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Human herpesviruses HHV-6A, HHV-6B & HHV-7. Chapter 13. Zerr DM & Ogata M. HHV-6A and HHV-6B in recipients of hematopoietic cell transplantation
人类疱疹病毒 HHV-6A、HHV-6B
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Flammand L, Lautenschlager I, Krueger G, Ablashi E (編)]
通讯作者:
Ablashi E (編)
同種造血細胞移植後HHV-6脳炎の発症にはHHV-6再活性化のレベルとIL-6高値が関連する
HHV-6 再激活水平和高 IL-6 水平与异基因造血细胞移植后 HHV-6 脑炎的发生有关。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Nakayama T, Nishiwaki S, Saito S, Ozaki T, Takahashi Y, Maruyama S, Nishida T, Murata M, Kojima S, Naoe T., 高野久二子]
通讯作者:
高野久二子
Plasma human herpesvirus 6 (HHV-6) DNA loads and interleukin-6 concentration as factors in the development of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation
血浆人疱疹病毒 6 (HHV-6) DNA 载量和白细胞介素 6 浓度是同种异体造血干细胞移植后发生 HHV-6 脑炎的因素
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takano K, Satou T, Ogata M, Ikewaki J, Kohno K, Miyazaki Y, Ohtsuka E, Saburi Y,Kadota J]
通讯作者:
Saburi Y,Kadota J
DOI:
10.1093/cid/cit358
发表时间:
2013-09-01
期刊:
CLINICAL INFECTIOUS DISEASES
影响因子:
11.8
作者:
[Ogata, Masao, Satou, Takako, Fukuda, Takahiro]
通讯作者:
Fukuda, Takahiro
DOI:
10.1038/bmt.2012.121
发表时间:
2013-02-01
期刊:
BONE MARROW TRANSPLANTATION
影响因子:
4.8
作者:
[Ogata, M., Satou, T., Kadota, J.]
通讯作者:
Kadota, J.
共 22 条
Dirac electrons in solids
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批准号:24244053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.79万
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财政年份:2012
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负责人:OGATA Masao
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依托单位:
Search for novel low-energy states in strongly correlated electron systems
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批准号:15540333
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:OGATA Masao
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依托单位:
Theoretical study of anomalous liquid states in low-dimensional fermion systems
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批准号:10203206
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas (B)
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资助金额:$2.82万
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财政年份:1998
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负责人:OGATA Masao
-
依托单位:
Theory on vortex states in anisotropic superconductors with strong correlation
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批准号:10640334
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
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财政年份:1998
-
负责人:OGATA Masao
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依托单位: