Studies on the mechanisms for the prevention of diabetes in NOD mice by AIRE expression

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Because AIRE deficiency results in the development of organ-specific autoimmune disease, we attempted to prevent the development of autoimmune diseases by the overexpression of AIRE gene. For this purpose, we introduced human AIRE gene into the oocytes obtained from NOD mice, a strain that spontaneously develops type I diabetes. One line, which showed highest expression of human AIRE, out of four, showed resistance to the development of diabetes. It might be possible to unravel the roles of AIRE in the establishment of self tolerance by studying the mechanisms how overexpressed AIRE could prevent the autoimmunity in this experimental system.