The role of IL-25 receptor expressed on eosinophil lineage-committed progenitor

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Recently, we revealed that eosinophil lineage-committed progenitor (EoP) express both receptors for IL-25 and IL-33, which are members of epithelial cell-derived cytokines, but the role of these rececptors remain unknown. IL-33 stimulated EoP produced Th2 and pro-inflammtory cytokines, such as IL-4, 6, 13, suggesting that IL-33-stimulated EoP may serve not only as progenitor cell in eosinophil development but also as effector cell in allergic inflammation. Intraperitoneal administration of IL-25 and IL-33 induced the exclusive expansion of EoP and mature eosinophils, suggesting that both cytokines should be critical regulators in eosinophil hematopoiesis.