Analysis of the role transcription factors, especially c-Maf, play in the differentiation and functions of T helper cells

在对t细胞特异性c-Maf转基因（Tg）小鼠的分析中，我们观察到Tg - Th细胞具有效应/记忆表型。将WT - Th细胞转入Rag2缺陷小鼠体内诱导效应/记忆Th细胞时，这些细胞也高水平表达c-Maf。基于这些观察结果，我们对c-Maf缺陷的Th细胞进行了转录组分析。我们还分析了来自外周血的人原始/中枢记忆/效应记忆Th细胞，证实了MAF在人记忆Th细胞中的表达也显著增加。

In the analysis of T-cell specific c-Maf transgenic (Tg) mice, we observed that Tg Th cells have effector/memory phenotypes. When effector/memory Th cells were induced by transferring WT Th cells into Rag2 deficient mice, these cells also expressed c-Maf at high level. Based on these observations, we performed transcriptome analysis of c-Maf deficient Th cells. We also analyzed human naive/central memory/effector memory Th cells derived from peripheral blood and confirmed that the expression of MAF was also increased significantly in human memory Th cells.