Clarification of the mechanisms of intracellular trafficking of TNF

阐明 TNF 细胞内运输机制

• 批准号: 23591464
• 负责人: HORIUCHI Takahiko
• 金额: $ 3.49万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591464/
• 关键词: TNF; サイトカイン; 輸送

In the present study, we studied the mechanisms for intracellular trafficking of TNF, which is a crucial step for TNF production and secretion. By using human-derived cell lines, the effects of the inhibition and/or overproduction of the members of SNARE family on the TNF production and secretion was analyzed. STX4, VAMP3 and Vti1b were involved in the intracellular trafficking of TNF.

在本研究中，我们研究了TNF的细胞内运输机制，这是TNF产生和分泌的关键步骤。通过使用人源性细胞系，分析SNARE家族成员的抑制和/或过量产生对TNF产生和分泌的影响。STX 4、VAMP 3和Vti 1b参与TNF的细胞内运输。

项目成果

我が国におけるTRAPS（TNF受容体関連周期性症候群）の特徴

日本TRAPS（TNF受体相关周期性综合症）的特点

• 作者: Watanabe T;Yamashita K;Sakurai T;et al;Hirofumi Shibata;松下 祥;堀内孝彦
• 通讯作者: 堀内孝彦

the Kyushu Sapporo SLE (KYSS) Study Group : The modifying effect of NAT2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages

九州札幌 SLE (KYSS) 研究小组：NAT2 基因型对系统性红斑狼疮与饮酒和富含咖啡因饮料之间关系的改变作用

• 发表时间: 2014
• 期刊: Arthritis Care Res(Hoboken)
• 作者: Kiyohara C;Washio M;Horiuchi T;Asami T;Ide S;Atsumi T;Kobashi G;Takahashi H;Tada Y
• 通讯作者: Tada Y

Cigarette smoking, alcohol consumption and the risk of systemic lupus erythematosus : a case-control study in a Japanese population

吸烟、饮酒与系统性红斑狼疮的风险：日本人群的病例对照研究

• 发表时间: 2012
• 期刊: J. Rheumatol
• 作者: Kiyohara C;Washio M;Horiuchi T;Tada Y;Asami T;Ide S;Atsumi T;Kobashi G;Takahashi H;and the Kyushu Sapporo SLE (KYSS) Study Group
• 通讯作者: and the Kyushu Sapporo SLE (KYSS) Study Group

Cigarette smoking, alcohol consumption and the risk of systemic lupus erythematosus: a case-control study in a Japanese population

吸烟、饮酒与系统性红斑狼疮的风险：日本人群的病例对照研究

• 发表时间: 2012
• 期刊: J Rheumatol
• 影响因子: 3.9
• 作者: Kiyohara C;Washio M;Horiuchi T;et al.
• 通讯作者: et al.

Purkinje Cell Protein 4 Positively Regulates Neurite Outgrowth and Neurotransmitter Release

• DOI: 10.1002/jnr.22688
• 发表时间: 2011-10-01
• 期刊: JOURNAL OF NEUROSCIENCE RESEARCH
• 影响因子: 4.2
• 作者: Harashima, Shin-ichi;Wang, Yu;Inagaki, Nobuya
• 通讯作者: Inagaki, Nobuya