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Clarification of the mechanisms of intracellular trafficking of TNF

Clarification of the mechanisms of intracellular trafficking of TNF
阐明 TNF 细胞内运输机制
批准号:
23591464
负责人:
HORIUCHI Takahiko
金额:
$3.49万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
In the present study, we studied the mechanisms for intracellular trafficking of TNF, which is a crucial step for TNF production and secretion. By using human-derived cell lines, the effects of the inhibition and/or overproduction of the members of SNARE family on the TNF production and secretion was analyzed. STX4, VAMP3 and Vti1b were involved in the intracellular trafficking of TNF.
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会议论文
我が国におけるTRAPS(TNF受容体関連周期性症候群)の特徴
日本TRAPS(TNF受体相关周期性综合症)的特点
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Watanabe T, Yamashita K, Sakurai T, et al, Hirofumi Shibata, 松下 祥, 堀内孝彦]
通讯作者: 堀内孝彦
the Kyushu Sapporo SLE (KYSS) Study Group : The modifying effect of NAT2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages
九州札幌 SLE (KYSS) 研究小组:NAT2 基因型对系统性红斑狼疮与饮酒和富含咖啡因饮料之间关系的改变作用
DOI: --
发表时间: 2014
期刊: Arthritis Care Res(Hoboken)
影响因子: --
作者: [Kiyohara C, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y]
通讯作者: Tada Y
DOI: --
发表时间: 2012
期刊: J. Rheumatol
影响因子: --
作者: [Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, and the Kyushu Sapporo SLE (KYSS) Study Group]
通讯作者: and the Kyushu Sapporo SLE (KYSS) Study Group
Cigarette smoking, alcohol consumption and the risk of systemic lupus erythematosus: a case-control study in a Japanese population
吸烟、饮酒与系统性红斑狼疮的风险:日本人群的病例对照研究
DOI: --
发表时间: 2012
期刊: J Rheumatol
影响因子: 3.9
作者: [Kiyohara C, Washio M, Horiuchi T, et al.]
通讯作者: et al.
38
    Immunological function of transmembrane TNF-alpha
    • 批准号:
      20591172
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2008
    • 负责人:
      HORIUCHI Takahiko
    • 依托单位:
    Functional analyses for transmembrane TNF-alpha
    • 批准号:
      17591048
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      HORIUCHI Takahiko
    • 依托单位:
    Analysis of the function of membrane TNF-α
    • 批准号:
      14570418
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.92万
    • 财政年份:
      2002
    • 负责人:
      HORIUCHI Takahiko
    • 依托单位:
    Functional analysis of membrane TNF-α
    • 批准号:
      12670429
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2000
    • 负责人:
      HORIUCHI Takahiko
    • 依托单位:
    海外基金