Antimicrobial chemotherapy for biofilm-related infection caused by multidrug-resistant pathogen

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It is known that bacteria which attached to the implants such as the artificial joints of the orthopedics field or the prosthetic valves of the cardiovascular surgery form biofilms. In this case, because an antibacterial agent is hard to arrive at the bacteria in the biofilms, an infectious disease is intractable. In this study, it was found that the clarithromycin of macrolide removed around 50% of biofilms formed by Staphylococcus aureus. Therefore the biofilm formed contamination model on the implant by MRSA which became the problem for nosocomial infection was made.It was confirmed that biofilm formed S. aureus strains were sterilized 72 hours later by combination of clarithromycin and daptomycin treatment.