Role of calcium signaling on the endodermal stem cells in the metabolic syndrom from childhood.

代谢综合征是肥胖、高脂血症、高血压、糖尿病等动脉粥样硬化性疾病的高危人群。近年来发现本病多在儿童期发病。本研究利用组织特异性钙网蛋白基因敲除小鼠和过表达小鼠分别建立了内胚层干细胞，并分析了其在钙信号中的作用。从钙信号对基因表达功能和蛋白质功能调节的角度阐明了代谢综合征的发病机制。

The metabolic syndrome is a high-risk group of arteriosclerotic diseases occurring such as obese, hyperlipidemia, hypertension and diabetes. It was elucidated that the onset of this metabolic syndrome was found in childhood recently. In this study, we established endodermal stem cells from calreticulin knockout mice and overexpression mice with tissue-specific calreticulin, and analyzed the function in the calcium signals. We elucidated a mechanism of the onset of the metabolic syndrome from the viewpoint of calcium signal which was important to the adjustment of the function of gene expression and the protein function.