Role of Rab family small G proteins in the development of neuroblastoma cancer stem cells

超过50%的高危神经母细胞瘤患者经历了化疗耐药癌症干细胞（CSCs）引起的肿瘤复发。因此，它们的总体存活率仍低于40%。为了改善其预后，有必要了解神经母细胞瘤中csc如何产生和维持的分子机制。在本研究中，我们重点研究了膜交通的关键调节因子Rab家族小G蛋白（Rabs），并确定了Rabs中控制神经母细胞瘤CSCs发育的成员。

More than 50% of high-risk neuroblastoma patients have experienced tumor relapses caused by chemoresistant cancer stem cells (CSCs). Consequently, their overall survival rates remain less than 40%. To improve their prognosis, it is essential to understand the molecular mechanism of how CSCs are generated and maintained in neuroblastoma. In the present study, we have focused on the key regulators of membrane traffic, Rab family small G proteins (Rabs), and identified a member of Rabs controlling the development of neuroblastoma CSCs.