A randomized controlled trial on the efficacy of cognitive remediation therapy against cognitive disorder in schizophrenia.

NEAR的RCT没有招募足够的样本量。因此，我们还进行了一项准随机研究，使用19名精神分裂症患者参加为期6个月的NEAR治疗（NEAR组），12名患者在相同的时间内接受正常治疗（TAU组）。比较两组6个月内脑额叶区认知功能变化及对工作记忆任务（2-back）血流动力学反应的变化。与TAU组相比，NEAR组在运动和执行功能方面有显著改善，右额极区血流动力学反应也有显著增加。提示NEAR可能通过增强额叶皮层活动来改善认知功能。

Not enough sample size was recruited for RCT of NEAR. Therefore, a quasi-random study was run in addition, using 19 patients with schizophrenia participating in the NEAR session lasting for 6 months (NEAR group) and 12 being treated as usual for the same period (TAU group). Cognitive function change as well as the change in the hemodynamic response to a working memory task (2-back) in the frontal area within 6 months was compared between groups. NEAR group showed a significant improvement in motor and executive function as well as a significant increase in the hemodynamic response in the right frontopolar area as compared to TAU group. It was suggested that NEAR may improve cognitive function through its enhancing effect on frontal cortex activity.