An exploration for the reason about accumulation of Vitronectin in the mouse model of Tauopathy

Tau蛋白病小鼠模型中玻连蛋白蓄积原因的探讨

• 批准号: 23591735
• 负责人: MARUYAMA masahiro
• 金额: $ 3.33万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591735/
• 关键词: ビトロネクチン; タウモデルマウス; 脳萎縮; ビトロネクチン受容体; タウオパチーモデルマウス; タウオパチー; 中枢神経分子マーカー; インテグリン受容体; 再ミエリン化; 神経修復機構; オリゴデンドロサイト前駆細胞; 歯状回分子層; 中枢疾患分子マーカー

The accumulation of vitronectin(Vn) in the perforant pathway of hippocampal area was found in PS19 tau mice. The hippocampus of PS19 mice has been known as the primary region of pathology with hyperphosphorylated tau accumulation. Interestingly, less Vn showed more hippocampal atrophy in the PS19 mice. Crossbreeding of the PS19 mice with Vn null mice confirmed the enhanced hippocampal atrophy. These findings suggest that Vn may have a protective function against the neuronal loss in PS19 mice.

在PS19 tau小鼠海马区的穿通通路中发现了玻连蛋白（Vn）的积聚。已知PS19小鼠的海马是具有过度磷酸化tau积累的病理学的主要区域。有趣的是，在PS19小鼠中，较少的Vn显示更多的海马萎缩。PS19小鼠与Vn缺失小鼠的杂交证实了增强的海马萎缩。提示Vn对PS19小鼠神经元损伤具有保护作用。