An exploration for the reason about accumulation of Vitronectin in the mouse model of Tauopathy

在PS19 tau小鼠海马区的穿通通路中发现了玻连蛋白（Vn）的积聚。已知PS19小鼠的海马是具有过度磷酸化tau积累的病理学的主要区域。有趣的是，在PS19小鼠中，较少的Vn显示更多的海马萎缩。PS19小鼠与Vn缺失小鼠的杂交证实了增强的海马萎缩。提示Vn对PS19小鼠神经元损伤具有保护作用。

The accumulation of vitronectin(Vn) in the perforant pathway of hippocampal area was found in PS19 tau mice. The hippocampus of PS19 mice has been known as the primary region of pathology with hyperphosphorylated tau accumulation. Interestingly, less Vn showed more hippocampal atrophy in the PS19 mice. Crossbreeding of the PS19 mice with Vn null mice confirmed the enhanced hippocampal atrophy. These findings suggest that Vn may have a protective function against the neuronal loss in PS19 mice.