The development and clinical applications for non-invasive functional imaging using Arterial Spin Labeling (ASL) on 3T-MRI

动脉自旋标记(ASL)是一种无创性的MR血流灌注评价方法，可提供脑血流量(CBF)的量化值。然而，用这种方法定量测量CBF依赖于许多参数，包括脑的T1和动脉通过时间(Delta)。由于固定参数的误差，动脉通过时间对CBF计算的准确性影响最大。在本研究中，我们论证了采用多重PLD方法的ATT标测以及延迟补偿的rCBF计算的可行性。首先，我们已经证明了使用CBF和Delta两室模型制作ATT图的可行性，其次，通过比较来自相同患者的O2-PET和CASL-ATT，证明了ATT图的临床应用。提出了基于ASL的动脉侧CBV计算方法，并对其可行性和模型进行了评价。

Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment, which can provide a quantitative value of cerebral blood flow (CBF). However, quantitative measurement of CBF with this method depends on a number of parameters including T1 of brain and arterial transit time (DELTA). Arterial transit time has most significant effect for the accuracy of CBF calculation due to the errors in the fixed parameters. In the current study, we have demonstrated the feasibility of ATT mapping with multiple PLD approach as well as delay compensated rCBF calculation. We have demonstrated, first, the feasibility of making ATT map using a two-compartment model for CBF as well as DELTA, second, the clinical utility of ATT mapping by comparison of O2-PET and CASL-ATT obtained from the same patients. Moreover, the method of arterial side CBV calculation based on ASL has been proposed and its feasibility and model was evaluated.