Assessment of functional and anatomical imaging assessed by PET and cardiac MRI in diabetic cardiomyopathy

通过 PET 和心脏 MRI 评估糖尿病心肌病的功能和解剖成像

• 批准号: 23591798
• 负责人: MOMOSE Mitsuru
• 金额: $ 3.33万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591798/
• 关键词: diabetic cardiomyopathy; N-13 ammonia PET; myocardial flow reserve; cardiac MRI; myocardial blood flow; PET; 心筋血流量; ＰＥＴ; 糖尿病; 心筋血流; アンモニア

To assess whether diabetic cardiomyopathy (DMCM) is related to myocardial blood flow or flow reserve, 5 patients with low LVEF<45% (DMCM) and 12 patients with DM control (DMc) with normal LVEF underwent N-13 ammonia PET and cardiac MRI(CMR). Stress, rest myocardial blood flow (sMBF, rMBF) and myocardial flow reserve (MFR) by PET and EDV, ESV and EF by CMR were evaluated. There was no significant difference in routine clinical blood data, but significant difference in HbA1c (DMCM<DMc). There was no significant difference in sMBF, rMBF and MFR between the 2 groups. MFR was not correlated with LVEF, but showed negative correlation with age among the all patients. In conclusion, MBF or MFR is not likely to be a factor of pathogenesis for DMCM.

为探讨糖尿病心肌病（DMCM）与心肌血流或血流储备的关系，对5例低LVEF<45%（DMCM）患者和12例LVEF正常的DM对照（DMc）患者进行了N-13氨PET和心脏MRI（CMR）检查。PET测定负荷、静息心肌血流量（sMBF、rMBF）、心肌血流储备（MFR），CMR测定EDV、ESV、EF。两组临床血常规无显著性差异，但HbA 1c差异有显著性（DMCM<DMc）。两组sMBF、rMBF和MFR无显著差异。MFR与LVEF无相关性，但与年龄呈负相关。总之，MBF或MFR不太可能是DMCM的发病因素。