Evaluation of intravascular behavior and optimization of embolization microspheres for the paradigm shit of vascular embolotherapy

血管内行为的评估和栓塞微球的优化，用于血管栓塞治疗的范式

• 批准号: 23591819
• 负责人: OSUGA Keigo
• 金额: $ 3.24万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591819/
• 关键词: 血管塞栓術; 血管塞栓物質; 球状ビーズ; 塞栓深度; 血管ファントム

We developed a vessel phantom with variable flow-velocity for simulating intravascular behavior of embolization microspheres. The in-vivo study using canine models suggested that optimal embolization endpoint was different among mechanical properties of microspheres in addition to the target organ and purpose of embolization. To achieve the total ischemia of parenchyma organs like the kidney, complete embolization using microspheres with high elasticity and high viscoelasticity seemed necessary. To minimize the ischemic damage of hollow organs like the small intestine, limited embolization with microspheres equal to or larger than 500 micron seemed appropriate.

我们开发了一种具有可变流速的血管模型，用于模拟栓塞微球的血管内行为。使用犬模型的体内研究表明，除了栓塞的靶器官和目的外，最佳栓塞终点因微球的机械性能而异。为了实现肾脏等实质器官的完全缺血，需要使用具有高弹性和高粘弹性的微球进行完全栓塞。为了尽量减少小肠等中空器官的缺血性损伤，使用等于或大于 500 微米的微球进行有限栓塞似乎是合适的。