Evaluation of intravascular behavior and optimization of embolization microspheres for the paradigm shit of vascular embolotherapy

我们开发了一种可变流速的血管模型，用于模拟栓塞微球的血管内行为。使用犬模型的体内研究表明，除了靶器官和栓塞目的外，微球的机械性能也会导致最佳栓塞终点的不同。为了实现肾等实质器官的完全缺血，使用具有高弹性和高粘弹性的微球进行完全栓塞似乎是必要的。为了最大限度地减少小肠等中空器官的缺血性损伤，使用等于或大于500微米的微球进行有限栓塞似乎是合适的。

We developed a vessel phantom with variable flow-velocity for simulating intravascular behavior of embolization microspheres. The in-vivo study using canine models suggested that optimal embolization endpoint was different among mechanical properties of microspheres in addition to the target organ and purpose of embolization. To achieve the total ischemia of parenchyma organs like the kidney, complete embolization using microspheres with high elasticity and high viscoelasticity seemed necessary. To minimize the ischemic damage of hollow organs like the small intestine, limited embolization with microspheres equal to or larger than 500 micron seemed appropriate.