Evaluation of intravascular behavior and optimization of embolization microspheres for the paradigm shit of vascular embolotherapy

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We developed a vessel phantom with variable flow-velocity for simulating intravascular behavior of embolization microspheres. The in-vivo study using canine models suggested that optimal embolization endpoint was different among mechanical properties of microspheres in addition to the target organ and purpose of embolization. To achieve the total ischemia of parenchyma organs like the kidney, complete embolization using microspheres with high elasticity and high viscoelasticity seemed necessary. To minimize the ischemic damage of hollow organs like the small intestine, limited embolization with microspheres equal to or larger than 500 micron seemed appropriate.