Establishment and validation of corrected SUVmax correlated with prognosis following stereotactic body radiotherapy for non-small cell lung cancer

SUVmax是FDG-PET蓄积的一个指标，有望成为各种癌症的预后因素。然而，它是一个相对指标，受肿瘤大小、呼吸运动、肿瘤背景、器械等因素的影响。我们用移动体模做了一个实验，并试图修正随着肿瘤大小和呼吸运动而修改的SUVmax。其次，根据非小细胞癌患者立体定向体部放疗的治疗结果数据，研究了校正后的SUVmax的可用性。结果表明，实际的SUVmax和校正后的SUVmax与局部控制和无病控制有很好的相关性。然而，校正的SUVmax并没有显示出与这些结果更相关。

SUVmax is an index of accumulation in FDG-PET, and is expected to be a prognostic factor of various cancer. However, it is a relative index and is affected by tumor size, respiratory movement, tumor background, instrument and so on. We made an experiment using moving phantom and tried to correct SUVmax modified with tumor size and respiratory movement. Next, availability of the corrected SUVmax was investigated on the treatment results data of stereotactic body radiotherapy for patients with non-small cell cancer.As results, actual SUVmax and corrected SUVmax were correlated well with local control and disease-free control. However, corrected SUVmax was not shown to be more correlated with those outcomes.