Investigation of the biological significance of collapsin response mediator protein (CRMP) in breast cancer

CRMP2 mRNA在乳腺癌组织中的表达显著降低，而其他CRMPs mRNA在正常乳腺组织和乳腺癌组织中的表达无明显差异。免疫组化显示CRMP2蛋白在乳腺癌组织中的表达也明显降低（P < 0.001）。磷酸化的CRMP2在乳腺癌细胞核中表达，而在正常乳腺细胞核中未见表达（P < 0.001）。此外，核磷酸化CRMP2表达增加的比例，组织学分级和三阴性亚型。CRMP2表达降低和核磷酸化CRMP2表达升高可能与乳腺癌进展相关。

The expression of CRMP2 mRNA was significantly decreased in breast cancer tissues, while that of the other CRMPs was similar between normal and breast cancer tissues. Immunohistochemistry revealed that CRMP2 protein expression was also decreased in breast cancer tissues (P < 0.001). Phosphorylated CRMP2 was observed in the nuclei of breast cancer cells but not in normal mammary cells (P < 0.001). Furthermore, nuclear phosphorylated CRMP2 expression was increased in proportion to the histological grade and triple-negative subtype. Reduced CRMP2 expression and elevated expression of nuclear phosphorylated CRMP2 may be associated with breast cancer progression.