Elucidation of the impact of chronic schistosomiasis japonica on recurrence and prognosis of the patients of hepatocellular carcinoma after hepatic resection and its mechanism.

阐明慢性日本血吸虫病对肝细胞癌肝切除术后复发及预后的影响及其机制。

• 批准号: 23591983
• 负责人: MATSUDA Masanori
• 金额: $ 3.08万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591983/
• 关键词: 日本住血吸虫症; 肝細胞癌; 肝内胆管癌; 肝切除; 免疫障害; 早期肝細胞癌; 免疫抑制状態; 腫瘍免疫; 日本住血吸虫

Proportion of hepatocellular carcinoma (HCC) patients with chronic schistosomiasis japonica (SJ) who underwent hepatic resection is about 18% in our department in recent years. Age in the SJ group was significantly higher and red blood cell count, IgM concentration and CD19 positive lymphocyte were significantly lower than in the non-SJ group. We assumed that deficiency in hematopoiesis and B cell function was adverse prognostic factor for survival after hepatic resection. Introduction of EOB-MRI and intraoperative contrast enhanced US and simultaneous treatment of early HCC prolonged survival after hepatic resection even in patients with chronic SJ.

近年来我科慢性日本血吸虫病（SJ）肝细胞癌（HCC）患者接受肝切除的比例约为18%。 SJ组的年龄显着高于非SJ组，红细胞计数、IgM浓度和CD19阳性淋巴细胞显着低于非SJ组。我们假设造血和 B 细胞功能缺陷是肝切除术后生存的不良预后因素。 EOB-MRI 和术中对比增强超声的引入以及早期 HCC 的同步治疗延长了肝切除术后的生存期，即使是慢性 SJ​​ 患者也是如此。

项目成果

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