Elucidation of the impact of chronic schistosomiasis japonica on recurrence and prognosis of the patients of hepatocellular carcinoma after hepatic resection and its mechanism.

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Proportion of hepatocellular carcinoma (HCC) patients with chronic schistosomiasis japonica (SJ) who underwent hepatic resection is about 18% in our department in recent years. Age in the SJ group was significantly higher and red blood cell count, IgM concentration and CD19 positive lymphocyte were significantly lower than in the non-SJ group. We assumed that deficiency in hematopoiesis and B cell function was adverse prognostic factor for survival after hepatic resection. Introduction of EOB-MRI and intraoperative contrast enhanced US and simultaneous treatment of early HCC prolonged survival after hepatic resection even in patients with chronic SJ.