Analysis of amino acid-signal transduction in the intestinal system, applying a new nipple-bottle feeding system and artificial milk formula for newborn mice.

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We have presented that feeding neonatal mice with glutamine-deleted artificial milk formula induced high incidence of colonic hemorrhage due to the epithelial cell death, applying a new nipple-bottle feeding system for newborn mice. IEC6 rat intestinal epithelial cells cultured with low concentration of glutamine underwent apoptosis.Glutamine deprivation might cause instability of the intestinal epithelial alignment by apoptosis.