Innovation of novel therapeutic approach to pancreatic cancer using galectin-3 and AMF

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Galectin-3 (Gal-3) is beta-galactoside-binding protein, having binding capacity with glycoprotein and glycolipid on a cell surface. Gal-3 engages in cell differentiation, organ formation, tumor progression, apoptosis and so on, however, precise mechanisms of them have not yet been clarified.We investigated the relationship between Gal-3 and pancreatic cancer, especially on cell proliferation, migration and invasion using pancreatic cancer cell lines. We also analyzed changes of tolerance toward anti-cancer drugs when expression level of Gal-3 was inhibited in the cell lines. Inhibition of Gal-3 expression led to inhibition of migration and invasion of the cells. It also augmented their susceptibility to anti-cancer agents, like gemcitabine and cisplatinum.