Development of artificial blood vessel using biocompatible nanofiber sheet as a scaffold to accerelate native tissue regeneration

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<Objective> We sought to evaluate the usefulness of polyglutamic acid nanofiber sheet as a scaffold on the artificial arterial vessel. <Methods> Polyglutamic acid nanofiber sheet was attached to the woven polylactic acid vessel graft, which was transplanted under the skin in the thigh of the rat and was replaced of the abdominal aorta of the rabbit. <Results> Early infiltration of the native fibroblast cells was observed on the graft under the skin. Graft replacing the aorta invited the thrombo-occlusion of the abodominal aorta followed by paraplegia. <Conclusion> Polyglutamic acid nanofiber sheet showed high histocompatibility, but its thrombogenicity excluded the possibility of its use as an artificial blood vessel.