Development of artificial blood vessel using biocompatible nanofiber sheet as a scaffold to accerelate native tissue regeneration

使用生物相容性纳米纤维片作为支架开发人造血管，以加速天然组织再生

• 批准号: 23592026
• 负责人: ISHIZAKA Toru
• 金额: $ 3.08万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592026/
• 关键词: ナノファイバー; 人工血管; 心臓血管外科学; 生体組織工学

<Objective> We sought to evaluate the usefulness of polyglutamic acid nanofiber sheet as a scaffold on the artificial arterial vessel. <Methods> Polyglutamic acid nanofiber sheet was attached to the woven polylactic acid vessel graft, which was transplanted under the skin in the thigh of the rat and was replaced of the abdominal aorta of the rabbit. <Results> Early infiltration of the native fibroblast cells was observed on the graft under the skin. Graft replacing the aorta invited the thrombo-occlusion of the abodominal aorta followed by paraplegia. <Conclusion> Polyglutamic acid nanofiber sheet showed high histocompatibility, but its thrombogenicity excluded the possibility of its use as an artificial blood vessel.

<Objective>我们试图评估聚谷氨酸纤维膜作为人工动脉血管支架的有用性。<Methods>将聚谷氨酸纤维膜贴附于编织的聚乳酸血管移植物上，将其移植于大鼠大腿皮下，并替代兔腹主动脉。<Results>在皮肤下的移植物上观察到天然成纤维细胞的早期浸润。移植物替代主动脉导致腹主动脉血栓闭塞，随后发生截瘫。<Conclusion>聚谷氨酸片具有良好的组织相容性，但其致血栓性使其不能作为人工血管使用。