Study of myocardial protection by sympathetic nerve stimulation using a new SPY-Q system myocardial blood flow evaluation

新型SPY-Q系统心肌血流评估交感神经刺激心肌保护研究

• 批准号: 23592031
• 负责人: TOMITA Shigeyuki
• 金额: $ 3.49万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592031/
• 关键词: 交感神経刺激; 高周波刺激; 心筋酸素代謝; 心筋保護法; Ganglion Plexus; 副交感神経刺激; 心筋血流; 電気的心筋保護法; 神経刺激心停止; 心筋酸素飽和度

The purpose of this study is to obtain safety cardiac arrest by sustained stimulation of bilateral sympathetic nerve and Ganglion Plexus. Using a pen type bipolar stimulation device (25-30 Hz, rectangular bipolar pulse, output 8 V, pulse width 0.4 ms) with distance between electrodes 3 mm, a stable cardiac arrest was obtained during 30 minutes. During stimulation (30 minutes), cardiac arrest was obtained and after stopping stimulation, heart beating was started immediately. Heart rate and systemic blood pressure were recovered to the controlled value in about 10 minutes. During cardiac arrest, myocardial blood flow and myocardial oxygen saturation were not decreased. The new cardiac protection of the sympathetic nerve stimulation resulted in safe and useful methods without decreasing of cardiac dysfunction and myocardial oxygen metabolism.

本研究的目的是通过持续刺激双侧交感神经和神经节丛获得安全的心脏骤停。使用笔型双极刺激装置（25-30 Hz，矩形双极脉冲，输出8V，脉冲宽度0.4ms），电极之间的距离为3 mm，在30分钟期间获得稳定的心脏停搏。在刺激期间（30分钟），获得心脏骤停，停止刺激后，立即开始心脏跳动。心率和体循环血压在10分钟左右恢复到对照值。在心脏骤停期间，心肌血流量和心肌氧饱和度未降低。交感神经刺激是一种安全有效的心脏保护新方法，不降低心功能和心肌氧代谢。