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Role of ARNT-Hypoxia Inducible Factor 1 in development of pulmonary arterial hypertension

Role of ARNT-Hypoxia Inducible Factor 1 in development of pulmonary arterial hypertension
ARNT-缺氧诱导因子 1 在肺动脉高压发展中的作用
批准号:
23592039
负责人:
SUGANO Mikio
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
Hypoxia-inducible factor (HIF) specifically in endothelial cells of the pulmonary artery seems to play an important role in development of pulmonary arterial hypertension. Role of HIF was investigated using monocrotaline-induced pulmonary arterial hypertension model mice lacking Hif-1 beta. The endothelin upregulation through HIF may be one of the potential pathways for the pulmonary artery remodeling in the lung tissue.
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会议论文
Functional restoration of endothelial cells of the cry opreserved heart valve
冷冻保存心脏瓣膜内皮细胞的功能恢复
DOI: 10.1007/s11748-010-0711-y
发表时间: 2011
期刊: Gen Thorac Cardiovasc Surg
影响因子: --
作者: [N. Hatano, H Suzuki, Y. Itoh & K. Muraki, Fujimoto E]
通讯作者: Fujimoto E
In situ Observation of Crack Growth in Structural Ceramics and Microstructural Characterization
  • 批准号:
    09650728
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.3万
  • 财政年份:
    1997
  • 负责人:
    SUGANO Mikio
  • 依托单位:
Crack Growth Mechanism in Structural Ceramics and Microstructural Analysis
  • 批准号:
    07650778
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.34万
  • 财政年份:
    1995
  • 负责人:
    SUGANO Mikio
  • 依托单位: