Role of ARNT-Hypoxia Inducible Factor 1 in development of pulmonary arterial hypertension
Role of ARNT-Hypoxia Inducible Factor 1 in development of pulmonary arterial hypertension
批准号:
23592039
负责人:
SUGANO Mikio
金额:
$3.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Hypoxia-inducible factor (HIF) specifically in endothelial cells of the pulmonary artery seems to play an important role in development of pulmonary arterial hypertension. Role of HIF was investigated using monocrotaline-induced pulmonary arterial hypertension model mice lacking Hif-1 beta. The endothelin upregulation through HIF may be one of the potential pathways for the pulmonary artery remodeling in the lung tissue.
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DOI:
10.1007/s11748-010-0711-y
发表时间:
2011
期刊:
Gen Thorac Cardiovasc Surg
影响因子:
--
作者:
[N. Hatano, H Suzuki, Y. Itoh & K. Muraki, Fujimoto E]
通讯作者:
Fujimoto E
In situ Observation of Crack Growth in Structural Ceramics and Microstructural Characterization
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批准号:09650728
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1997
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负责人:SUGANO Mikio
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依托单位:
Crack Growth Mechanism in Structural Ceramics and Microstructural Analysis
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批准号:07650778
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.34万
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财政年份:1995
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负责人:SUGANO Mikio
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依托单位: