A study of the neural differentiation and neural function of human cranial bone marrow stromal cells cultured under simulated microgravity

模拟微重力培养人颅骨骨髓基质细胞的神经分化和神经功能研究

• 批准号: 23592127
• 负责人: YAMAGUCHI SATOSHI
• 金额: $ 3.49万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592127/
• 关键词: ヒト頭蓋骨骨髄間質細胞; 微少重力環境; 神経再生; 間葉系幹細胞; 骨髄間質細胞; 脊髄損傷; ヒト頭蓋骨間葉系幹細胞; 微小重力環境

Human cranial bones are thought to originate from the cranial neural crest that plays important role for constructiong central nervous systems in the embryo. In this study, we have investigated human cranial bone marrow derived stem cell (hcBMSC) capacities for neural differentiation. We cultured BMSC under simulated microgravity conditions to facilitate functional recovery from neural injury.We show that hcBMSC has potency to differentiate into neural lineages better than the BMSC deriverd from illiac bone, and would be a novel alternative source of autologous adult stem cells for neural regenerative therapy.

人类的颅骨被认为起源于在胚胎中对中枢神经系统的构建起重要作用的颅神经脊。在这项研究中，我们研究了人颅脑骨髓来源干细胞(HcBMSC)向神经分化的能力。我们在模拟微重力条件下培养BMSC，以促进神经损伤后的功能恢复。我们发现，hcBMSC比从髂骨分化的BMSC具有更好的分化为神经系的潜能，有望成为神经再生治疗的一种新的自体成体干细胞的替代来源。