A study of the neural differentiation and neural function of human cranial bone marrow stromal cells cultured under simulated microgravity

人类颅骨被认为起源于颅神经嵴，在胚胎时期颅神经嵴对中枢神经系统的构建起着重要作用。在这项研究中，我们研究了人颅骨骨髓源性干细胞（hcBMSC）的神经分化能力。我们在模拟微重力条件下培养骨髓间充质干细胞，以促进神经损伤后的功能恢复，结果表明hcBMSC具有比髂骨来源的BMSC更好的神经分化潜能，有望成为神经再生治疗的一种新的自体成体干细胞来源。

Human cranial bones are thought to originate from the cranial neural crest that plays important role for constructiong central nervous systems in the embryo. In this study, we have investigated human cranial bone marrow derived stem cell (hcBMSC) capacities for neural differentiation. We cultured BMSC under simulated microgravity conditions to facilitate functional recovery from neural injury.We show that hcBMSC has potency to differentiate into neural lineages better than the BMSC deriverd from illiac bone, and would be a novel alternative source of autologous adult stem cells for neural regenerative therapy.