Towards molecular classification and individualized treatment of glioma

神经胶质瘤的分子分类和个体化治疗

• 批准号: 23592141
• 负责人: SASAKI Hikaru
• 金额: $ 3.33万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592141/
• 关键词: 神経膠腫; 術前補助療法; neoadjuvant; 個別化治療; 化学療法; 1p19q; MGMT; 脳腫瘍; 1p/19q; neoadjuvant chemotherapy

We have analyzed 140 WHO grade II-III gliomas by comparative genomic hybridization, and those tumors have been shown to be classified into clinically relevant subgroups based on genetic profiles (gain on 7q vs 1p19q codeletion vs gain of 7/loss of 10q). Molecular genetic analyses of skull base chordomas have revealed that gain on 2p, lack of irradiation, and expression of brachyury (important protein on notochord development) were negatively associated with the risk of recurrence of those tumors.We have shown that molecular-guided upfront chemotherapy, i.e. upfront chemotherapy for gliomas suggested to be chemosensitive based on molecular analyses, could provide, following tumor volume decrease by chemotherapy, chance of radical resection that was not initially possible in significant portion of those tumors. We have also confirmed that combination of tumor calcification and surface tumor localization predicted presence of 1p19q codeletion with high positive predictive value.

我们通过比较基因组杂交分析了140个WHO II-III级胶质瘤，并根据基因图谱将这些肿瘤分成临床相关的亚组(7q获得与1p19q共缺失VS获得7/10q丢失)。对颅底脊索瘤的分子遗传学分析表明，2p增强、缺乏照射和短缩蛋白(脊索发育的重要蛋白)的表达与肿瘤复发的风险呈负相关。我们已经表明，分子引导的前期化疗，即根据分子分析被认为是化疗敏感的胶质瘤的前期化疗，可以提供在化疗后肿瘤体积缩小后的根治性切除的机会，这在很大一部分肿瘤中最初是不可能的。我们还证实，肿瘤钙化和表面肿瘤定位相结合预测存在1p19q共缺失，具有很高的阳性预测价值。

项目成果

グリオーマの化学療法

胶质瘤化疗

• 发表时间: 2008
• 期刊: Cur insights in neurol sci 26(20)
• 作者: 佐川元保;薄田勝男;土原一真;相川広一;町田雄一郎;田中良;上野正克;中川研;佐久間勉;田中実
• 通讯作者: 田中実

頭蓋底脊索腫の分子生物学的特徴と予後因子の検討

颅底脊索瘤的分子生物学特征及预后因素检查

• 作者: 北村洋平;佐々木光;木村徳宏;三輪 点;高橋里史;河瀬 斌;吉田一成
• 通讯作者: 吉田一成

Surgical navigation-assisted endoscopic biopsy is feasible for safe and reliable diagnosis of unresectable solid brain tumors

手术导航辅助内镜活检可安全可靠地诊断不可切除的实体脑肿瘤

• DOI: 10.1007/s10143-013-0467-9
• 发表时间: 2013
• 期刊: Neurosurg Rev
• 影响因子: 2.8
• 作者: 5 Nagahisa S;Watabe T;Sasaki H;Nishiyama Y;Hayashi T;Hasegawa M;Hirose Y
• 通讯作者: Hirose Y

Survey of the prognostic factors in 1p/19q codeleted gliomas

1p/19q 共缺失胶质瘤的预后因素调查

• 作者: Hayashi S;Sasaki H;Kimura T;Nakamura T;Miwa T;Hirose Y;Yoshida K
• 通讯作者: Yoshida K

脳腫瘍における術前補助療法

脑肿瘤的新辅助治疗

• 发表时间: 2014
• 期刊: 癌と化学療法
• 作者: 佐々木光;西山悠也;吉田一成
• 通讯作者: 吉田一成