Development of an animal model in which neurogenic intermittent claudication is reproduced

神经源性间歇性跛行是腰椎管狭窄症的特征症状。在本研究中，复制了与间歇性跛行相对应的异常神经元活动，以了解其病理生理学。在腰椎管狭窄动物模型上，马尾神经受压后异常感觉活动增加，低氧时这种反应进一步增强，高氧时这种反应减弱。反应程度与背根神经节供氧有关。这些结果表明，慢性压迫感觉神经敏化和供氧动力学是神经源性间歇性跛行的主要因素。

Neurogenic intermittent claudication is a characteristic symptom of lumbar spinal canal stenosis. In the present study, abnormal neuronal activities corresponding to intermittent claudication was reproduced to understand the pathophysiology. Using animal model of lumbar canal stenosis, abnormal sensory activities was increased by compression of cauda equina.This reaction was further increased by hypoxic condition, and decreased by hyper-oxygenic condition. The degree of reaction was related to oxygen supply to dorsal root ganglia. These results indicated that sensory nerve sensitization by chronic compression and dynamics of oxygen supply are major factors of neurogenic intermittent claudication.