Simultaneous gradual lengthening of proximal and distal nerve stumps for repair of chronic peripheral nerve defect.

通过逐渐延长近端和远端神经残端，观察大鼠坐骨神经慢性损伤15 mm缺损后的神经再生情况。在延长的近端残端，整个残端分布着雪旺细胞和轴突。在加长的远端残端，雪旺细胞沿全长存在。整个神经干被拉长。神经再生与端到端延迟缝合无神经缺损相当。我们展示了直接渐进延长近端和远端神经残端治疗慢性节段性神经缺损的可行性。

We investigated nerve regeneration of rat sciatic nerves after chronic injury of 15 mm-defect by the gradual lengthening of proximal and distal nerve stumps. In the lengthened proximal stump, Schwann cells and axons existed along the whole nerve stump. In the lengthened distal stump, Schwann cells exist along the overall length. The whole nerve trunk was lengthened.The nerve regeneration was comparable with the delayed end-to-end suture without nerve defect. We showed the feasibility of direct gradual lengthening of proximal and distal nerve stumps for the treatment of chronic segmental nerve defect.