Therapeutic effects for spinal cord injury with magnetic targeting of cell transplantation.

本研究旨在探讨磁靶向细胞移植治疗脊髓损伤的疗效。此前，我们报道了一种使用磁靶向的新细胞递送系统的开发。在本研究中，通过在成年SD大鼠脊髓上放置25g棒90秒来诱导脊髓挫伤。磁化组在T7节段椎旁肌肉内放置一块钕磁铁，而非磁化组在同一脊髓水平放置一块非磁性金属。两组均将磁性标记的骨髓基质细胞(BMSCs)注入蛛网膜下腔。磁体组后肢运动功能较非磁体组有明显改善。该细胞给药系统有望成为临床应用于脊髓损伤治疗的一种有用的方法。

The purpose of this study was to investigate the therapeutic effects with magnetic targeting of cell transplantation for spinal cord injury (SCI). Previously, we reported the development of a new cell delivery system using magnetic targeting. In the current study, contusion SCI was induced by placing a 25 g rod onto the spinal cord for 90 seconds in adult SD rats. A neodymium magnet was placed in the paravertebral muscles at the T7 level in the magnet group, whereas a nonmagnet metal was placed at the same spinal cord level in the nonmagnet group. Magnetically labeled bone marrow stromal cells (BMSCs) were injected into the subarachnoid space in both group. Hindlimb motor function of the magnet group demonstrated significant improvement compared with that of the nonmagnet group. This cell delivery system may be a useful method for future clinical application in the treatment of SCI.