Therapeutic effects for spinal cord injury with magnetic targeting of cell transplantation.

磁靶向细胞移植治疗脊髓损伤的疗效。

• 批准号: 23592165
• 负责人: TANAKA Nobuhiro
• 金额: $ 3.33万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592165/
• 关键词: 脊髄損傷; 神経幹細胞; 脊髄再生; 磁気ターゲティング; 移植・再生医療; 生体材料; 磁性

The purpose of this study was to investigate the therapeutic effects with magnetic targeting of cell transplantation for spinal cord injury (SCI). Previously, we reported the development of a new cell delivery system using magnetic targeting. In the current study, contusion SCI was induced by placing a 25 g rod onto the spinal cord for 90 seconds in adult SD rats. A neodymium magnet was placed in the paravertebral muscles at the T7 level in the magnet group, whereas a nonmagnet metal was placed at the same spinal cord level in the nonmagnet group. Magnetically labeled bone marrow stromal cells (BMSCs) were injected into the subarachnoid space in both group. Hindlimb motor function of the magnet group demonstrated significant improvement compared with that of the nonmagnet group. This cell delivery system may be a useful method for future clinical application in the treatment of SCI.

这项研究的目的是研究脊髓损伤细胞移植（SCI）的磁靶向的治疗作用。以前，我们报告了使用磁靶向的新细胞输送系统的开发。在当前的研究中，通过在成年SD大鼠中将25 g杆放在脊髓上90秒来诱导挫伤SCI。磁铁组的T7水平的椎骨肌肉中放置了一个neododmium磁铁，而在非马格内特组的同一脊髓水平上，将非磁铁金属放置。两组的磁性标记的骨髓基质细胞（BMSC）被注射到蛛网膜下腔中。与非魔法组相比，磁铁组的后肢运动功能显示出显着改善。该细胞输送系统可能是对SCI治疗的未来临床应用的有用方法。

项目成果

脊髄損傷に対するヒト末梢血由来CD133陽性細胞移植と外磁場デリバリーの効果

人外周血CD133阳性细胞移植和外磁场递送对脊髓损伤的影响

• 发表时间: 2011
• 作者: 藤岡悠樹;亀井直輔;越智光夫
• 通讯作者: 越智光夫

Therapeutic Effects With Magnetic Targeting of Bone Marrow Stromal Cells in a Rat Spinal Cord Injury Model

• DOI: 10.1097/brs.0b013e3181eb9fb0
• 发表时间: 2011-05-20
• 期刊: SPINE
• 影响因子: 3
• 作者: Sasaki, Hirofumi;Tanaka, Nobuhiro;Ochi, Mitsuo
• 通讯作者: Ochi, Mitsuo