Osteoconductive effect of spatial design and thermal oxidation on Pure Ti and Ti-15Zr-4Ta-4Nb alloy

当植入骨缺损时，钛及其合金表面的磷灰石形成可有效诱导骨传导性。其中一种方法是“GRAPE技术”，通过该技术对钛及其合金进行开槽和热处理。本研究的目的是研究在骨缺损中使用植骨植入时该技术的骨传导效应。采用该技术处理的Ti-15 Zr-4 Nb-4 Ta合金，我们评估了成骨细胞在该合金上的生长形态、增殖能力和分化活性。结果表明，采用GRAPE技术处理的Ti-15 Zr-4 Nb-4 Ta合金可提高成骨细胞的生长速度和分化，从而实现良好的骨固定。

Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects . One of these approaches is "GRAPE Technology," by which titanium and its alloys is grooved and thermally treated. The aim of this study was to investigate the osteoconductive effects of this technology when implanted using bone grafting in bony defects. Using Ti-15Zr-4Nb-4Ta alloy processed by this technique, we assessed the growth morphology, proliferative capacity, and differentiation activity of osteoblasts on the alloy. It was suggested that Ti-15Zr-4Nb-4Ta alloy processed employing GRAPE Technology, might enhance the growth rate and differentiation of osteoblasts to achieve favorable bone fixation .