The effect of exercise training on ischemia-reperfusion injury of the steatoliver

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Steatotic livers are known to be vulnerable to ischemia-reperfusion (I/R) injury during hepatic surgery and liver transplantation. Exercise training is recommended to prevent obesity-associated disorders. However, it remains unknown whether exercise training attenuates I/R injury of steatotic liver. We determined, using the hyperphagic, Otsuka Long-Evans Tokushima Fatty (OLETF) rat and the control Long-Evans Tokushima Otsuka (LETO) rat, effects of exercise training on I/R injury under both anesthesia and isolated liver perfusion. Running training was given on a motorized treadmill for four weeks from 19-th week. In both preparations of isolated perfused livers and anesthetized rats, I/R-induced liver injury was greater in the OLETF rats than that of LETO rats. Exercise training prevented the development of steatotic livers and attenuated the I/R injury, as observed in non-exercise OLETF rats. In conclusion, exercise training attenuates I/R injury of steatotic livers from OLETF rats.