Effects of inhalation and intravenous anesthetic drugs for Ca2+ uptake capacity and respiratory function in mitochondria of the platelets.

在新鲜分离和透化的人血小板中，常用麻醉剂七氟烷和丙泊酚在临床相关浓度下刺激线粒体呼吸能力的某些方面。在较高浓度下，这些药物显示出对复合物I和II支持的受体的剂量依赖性抑制。七氟烷和丙泊酚诱导的呼吸能力增加可能是有益的，呼吸抑制可能与长期或过度暴露的情况有关，特别是在这些麻醉剂的组织蓄积情况下。

In freshly isolated and permeabilized human platelets the commonly used anesthetic agents sevoflurane and propofol stimulate certain aspects of mitochondrial res- piratory capacity at clinically relevant concentrations. At higher concentrations, these agents displayed a dose- dependent inhibition of complex I and II-supported res- piration. The increased respiratory capacity induced by sevoflurane and propofol might be beneficial and the inhibition of respiration could be relevant to situa- tions of prolonged or excessive exposure, especially in situations of tissue accumulation of these anesthetic agents.