Effects of inhalation and intravenous anesthetic drugs for Ca2+ uptake capacity and respiratory function in mitochondria of the platelets.

吸入和静脉麻醉药物对血小板线粒体 Ca2+ 摄取能力和呼吸功能的影响。

• 批准号: 23592267
• 负责人: NOGUCHI MASASHI
• 金额: $ 2.41万
• 依托单位: Tokyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592267/
• 关键词: ミトコンドリア; 麻酔薬; 国際研究者交流; スウェーデン

In freshly isolated and permeabilized human platelets the commonly used anesthetic agents sevoflurane and propofol stimulate certain aspects of mitochondrial res- piratory capacity at clinically relevant concentrations. At higher concentrations, these agents displayed a dose- dependent inhibition of complex I and II-supported res- piration. The increased respiratory capacity induced by sevoflurane and propofol might be beneficial and the inhibition of respiration could be relevant to situa- tions of prolonged or excessive exposure, especially in situations of tissue accumulation of these anesthetic agents.

在新鲜分离和通透性的人血小板中，常用的麻醉剂七氟醚和异丙酚在临床相关浓度下刺激线粒体呼吸能力的某些方面。在较高浓度下，这些药物对络合物I和II支持的呼吸表现出剂量依赖的抑制作用。七氟醚和异丙酚引起的呼吸量增加可能是有益的，呼吸抑制可能与长时间或过度暴露的情况有关，特别是在这些麻醉剂的组织蓄积情况下。

项目成果

The influence of anesthetic agents on mitochondrial function as determined by high-resolved respirometry of human blood cells

通过人血细胞高分辨率呼​​吸测量法测定麻醉剂对线粒体功能的影响

• 发表时间: 2012
• 作者: 臼井大記;内野博之
• 通讯作者: 内野博之