Effects of inhalation and intravenous anesthetic drugs for Ca2+ uptake capacity and respiratory function in mitochondria of the platelets.

在新鲜分离和渗透的人血小板中，常用的麻醉剂七氟醚和异丙酚在临床相关浓度下刺激线粒体呼吸能力的某些方面。在较高浓度下，这些药物对复合体I和复合体ii支持的呼吸表现出剂量依赖的抑制作用。七氟醚和异丙酚引起的呼吸能力增加可能是有益的，呼吸抑制可能与长时间或过量暴露有关，特别是在这些麻醉剂的组织积累的情况下。

In freshly isolated and permeabilized human platelets the commonly used anesthetic agents sevoflurane and propofol stimulate certain aspects of mitochondrial res- piratory capacity at clinically relevant concentrations. At higher concentrations, these agents displayed a dose- dependent inhibition of complex I and II-supported res- piration. The increased respiratory capacity induced by sevoflurane and propofol might be beneficial and the inhibition of respiration could be relevant to situa- tions of prolonged or excessive exposure, especially in situations of tissue accumulation of these anesthetic agents.