Evaluation of Glutamate and GABA in the Anterior Cingulate Gyrus of Chronic Pain Patients with MR Spectroscopy

本研究的主要目的是利用质子 MRS 确定慢性疼痛如何引起 ACC 神经活动的变化。使用配备 MRS 分析装置的 3 特斯拉 MR 装置，根据光谱峰确定该区域的 N-乙酰天冬氨酸 (NAA)、谷氨酸 (Glu) 和 GABA 水平。然后比较患者和对照组之间的NAA、Glu和GABA水平。与对照组相比，慢性疼痛患者组ACC中的NAA和GABA水平显着降低。有人提出，前扣带回抑制性神经传递效率的降低与慢性疼痛的病理学有关。

The main objective of this study is to determine how chronic pain can induce changes in nerve activity in the ACC using proton MRS. The N-acetylaspartate (NAA), glutamate(Glu), and GABA levels in the regions were determined from the spectral peaks, using 3-tesla MR device equipped with an MRS analytical device. The NAA, Glu, and GABA levels were then compared between the patient and control groups.The NAA and GABA levels in the ACC were significantly decreased in the chronic pain patient group compared to those in the control group. It was suggested that decreased inhibitory neurotransmission efficiency in the anterior cingulate gyrus is involved in the pathology of chronic pain.