Behavioral study on potassium channel openers as a novel remedy for neuropathic pain.

采用大鼠神经性疼痛模型，观察三组钾通道开放剂的镇痛作用。在鞘内或脑室内使用几种K通道打开剂，以检查坐骨神经慢性收缩损伤引起的机械、热和冷痛觉过敏的中枢效应。脊柱和脊柱上应用钙活化钾通道（Kca）开放剂可减轻机械性和冷痛觉过敏。另一方面，电压依赖性K通道和双孔域K通道的打开剂对大鼠痛觉过敏无影响。Kca通道打开剂可能在脊髓和大脑中发挥抗痛觉作用。

The analgesic effects of three groups of potassium (K) channel openers were examined using a rat neuropathic pain model. Several K channel openers were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia induced by chronic constriction injury to the sciatic nerve. Spinally- and supraspinally-applied calcium-activated potassium channel (Kca) openers attenuated mechanical and cold hyperalgesia. On the other hand, the openers of voltage-dependent K channel and two-pore-domain K channel had no effect on the hyperalgesia displayed in the rats. The Kca channel openers may exert antihyperalgesic effects both in the spinal cord and the brain.