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Functional analysis of isolated specific antibody to prostate cancer specific antigen using phage-display method

Functional analysis of isolated specific antibody to prostate cancer specific antigen using phage-display method
使用噬菌体展示法对前列腺癌特异性抗原分离的特异性抗体进行功能分析
批准号:
23592353
负责人:
SHIROKI Ryoichi
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
In Antibody project in Comprehensive Research Institute of Fujita Heath University, Human phage antibody library; AIMS5 library, was established using human extracted B lymphocyte from the almond of dozens of people, marrow, peripheral blood, umbilical cord blood. Applying the phage-display method, specific antibody to PSMA, prostate specific membrane antibody, (75-10) was isolated from this library using ICOS method, J Immunol Methods. 351:1-12, 2009. Specific antibody to PSMA (75-10) was demonstrated to show the specific prostate membane-specific reactivity to prostate cancer tissue (the specific stainability to cell surface membrane) and an in vitro cancer cytotoxicity in cultured and a clinical specimen of the prostate cancer.
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会议论文
Joint session of the European association of urology(EAU)and the Japanese urological association robot assisted radical prostatectomy
欧洲泌尿外科协会(EAU)与日本泌尿外科协会机器人辅助根治性前列腺切除术联席会议
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Kurosawa G,Sugiura M,Ando M,Shiroki R,Hoshinaga K,Kurosawa Y, et al., Otsuki H,Kuwahara Y,Tsukamoto T,Nakamura K,Shiroki R,Hoshinaga K, Shiroki R]
通讯作者: Shiroki R
抗PSMA抗体を用いた前立腺癌臨床検体の発現プロファイル解析
使用抗 PSMA 抗体对临床前列腺癌标本进行表达谱分析
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [引地克, 白木良一, 西野将, 河合昭浩, 深谷孝介, 彦坂和信, 平野泰広, 石瀬仁司, 深見直彦, 丸山高広, 佐々木ひと美, 日下守, 石川清仁, 星長清隆]
通讯作者: 星長清隆
Urinary neutrophil gelatinase-associated lipocalin(NGAL)is a potential non-invasive marker for renal scarring in patients with vesicoureteral reflux.
尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)是膀胱输尿管反流患者肾脏瘢痕形成的潜在非侵入性标志物。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Mitsui T, Moriya K, Kitta T, Kon M, Nonomura K, Ichino M,Kusaka M,Sasaki H,Maruyama T,Ishikawa K,Shiroki R,Hoshinaga K]
通讯作者: Ichino M,Kusaka M,Sasaki H,Maruyama T,Ishikawa K,Shiroki R,Hoshinaga K
Nerve-sparing procedure impacts on early recovery of postopetative urinary continence in patients treated with total urinary reconstruction technique in Robot-Assisted Radical Prostatectomy
机器人辅助根治性前列腺切除术中接受全尿路重建技术治疗的患者保留神经手术对术后尿失禁早期恢复的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Shiroki R,Maruyama T,Kusaka M, Hoshinaga K]
通讯作者: Hoshinaga K
18
    Analysis of biological function and efficacy of anti EGFR antibodies isolated from screening of human antibody phage display library specific to human renal cell carcinoma
    • 批准号:
      20591870
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2008
    • 负责人:
      SHIROKI Ryoichi
    • 依托单位:
    Analysis of antigen to renal cell carcinoma and establishment of cancer specific antibody teratment
    • 批准号:
      18591777
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.57万
    • 财政年份:
      2006
    • 负责人:
      SHIROKI Ryoichi
    • 依托单位:
    EXPERIMENTAL ANALYSIS OF VASCULER CHANGES IN CHRONIC ALLOGRAFT REJECTION USING HUMANIZED SCID MOUSE MODEL.
    • 批准号:
      14571526
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
      SHIROKI Ryoichi
    • 依托单位:
    Analysis of mechanisms in delayed xenograft and cellular rejection in xenotransplant between human and swine
    • 批准号:
      11671588
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.92万
    • 财政年份:
      1999
    • 负责人:
      SHIROKI Ryoichi
    • 依托单位: