Direct effect of 5 alpha reductase inhibitora and PDE5 inhibitor on prostatic tissue

在建立了改良的严重联合免疫缺陷小鼠异种移植模型后，我们评估了度他雄胺和他达拉非对人前列腺组织的组织学变化。我们的数据显示，与对照组相比，杜他司特和他达拉非治疗2个月后，细胞增殖指数显著降低，凋亡率显著增加。这些结果为这两种药物减少BPH患者的前列腺体积提供了治疗潜力。

We evaluated histological changes in human prostate tissue caused by dutasteride and tadalafil, after establishing a xenograft model with improved severe combined immunodeficient mice. Our data showed that a proliferation index was significantly reduced and apoptosis rate were significantly increased after 2 months of dutasteride and tadalafil treatment, compared with control. These results provide a therapeutic potential of both drugs for reducing prostate volume in patients with BPH.